Chromosome translocational defect, illustration 3 of 3. Translocational defects results from an exchange of genetic material between two defective chr

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Chromosome translocational defect, illustration 3 of 3. Translocational defects results from an exchange of genetic material between two defective chromosomes. This illustration shows chromosome 9 (green) and chromosome 22 (red). The translocational defect of these chromosomes (Philadelphia chromosome) is associated with chronic myeloid leukaemia (CML). Leukaemia is a cancer where certain blood cells form in excess. CML is a cancer affecting the myeloid tissue (bone marrow), specifically the white blood cell precursors (myeloblasts) that form a type of white blood cell known as granulocytes. For a sequence showing the translocation, see images C037/9428 to C037/9430.

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