. The Journal of laboratory and clinical medicine . tions. An injection of the corresponding benzyl molecular amount of benzylfumarate ( gm.) in oil was now made and produced a relaxation in lessthan one minute. This difference in onset of relaxation corresponds to thedifference in the rate of initial hydrolysis in vitro of these two esters. Vol-wiler and Vliet show that benzyl succinate hydrolyzes at the rate of 12 percent in 5 minutes, per cent in 15 minutes and per cent in 20 minutes;while benzyl fumarate hydrolyzes at the rate of 35 per cent in 5 minutes, percent in 15
. The Journal of laboratory and clinical medicine . tions. An injection of the corresponding benzyl molecular amount of benzylfumarate ( gm.) in oil was now made and produced a relaxation in lessthan one minute. This difference in onset of relaxation corresponds to thedifference in the rate of initial hydrolysis in vitro of these two esters. Vol-wiler and Vliet show that benzyl succinate hydrolyzes at the rate of 12 percent in 5 minutes, per cent in 15 minutes and per cent in 20 minutes;while benzyl fumarate hydrolyzes at the rate of 35 per cent in 5 minutes, percent in 15 minutes, and 43 per cent in 20 minutes when treated accordingto their method. After a period of two hours their rates of hydrolysis runcloser together, namely, 40 per cent for the succinate and 57 for the obtained also marked relaxations of the cats duodenum with otherbenzyl compounds. The records obtained with benzyl phenolate have al-ready been presented. Benzaldehyde was also included in our experiments. /.^ttuc xAv7n*»n-t*&4j,. Fig. 14.—Shows the action of benzaldehyde and benzyl ethyl ether on the duodenum of a cat. Figs. 12 and 13 show the action of monobenzyl-barbituric acid on theduodenum and antrum pylori of a cat. It produced a relaxation of both. Onthe antrum, the relaxation was preceded by an increase of vigor and decreaseof frequency of the movements. The antrum experiment was made accordingto the Jackson method.* Fig. 14 shows the action of benzaldehyde and benzyl ethyl ether on theduodenum of a cat. The benzyl ethyl ether has a marked depressing effecton the respiration, even upon inhalation. Injected intravenously, it stoppedthe respiration and produced a gasping effect. This gasping may be noticedin the tracing by the downward strokes of the lever after the duodenum hadrelaxed. Artificial respiration was applied but failed to revive the animal,the heart having stopped. Fig. 15 shows the relaxation of the isolated uterus of a virgin guineapig prod
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