Manual of pathology : including bacteriology, the technic of postmortems, and methods of pathologic research . Soc. de Biol., 1904, Ivi, p. 153. See technic of Blood Examination, Part III, Chapter I. TTMokS. 351 equivalent to saying that the nion- tluid the intercellular sul>stance,the more malignant the tumor. Fluidity of the intercellular substanceimplies that the neoplastic cells are loosely bound together; this lackof cohesion between the elements of the tumor permits of the readydislodgement of one or more cells, or masses of cells, and hence favorsdisplacement of the tumor elements in
Manual of pathology : including bacteriology, the technic of postmortems, and methods of pathologic research . Soc. de Biol., 1904, Ivi, p. 153. See technic of Blood Examination, Part III, Chapter I. TTMokS. 351 equivalent to saying that the nion- tluid the intercellular sul>stance,the more malignant the tumor. Fluidity of the intercellular substanceimplies that the neoplastic cells are loosely bound together; this lackof cohesion between the elements of the tumor permits of the readydislodgement of one or more cells, or masses of cells, and hence favorsdisplacement of the tumor elements into the lymphatics and blood-vessels. The fluidity of the intercellular substance may be j)artly judgedbv the consistency of the tumor; a soft, almost fluctuating tumor, pos-sesses but little firmness in the intercellular substance. Such soft,pseudofiuctuating tumors are not infrequent among the author has known of one or more instances in which the surgeonhas cut into a sarcoma under the impression that he was dealing with acvst or a cold abscess. Indeed, the cellular elements of some of the. Fig. 104.— Incised SuRrace of Part or One Lobe, Secondarv serous surface is shown in Fig. 193. (Natural sire.) small, round-cell sarcomata are so attached that a needle—forexample, an exploring needle—passed into the tumor may not infre-quentlv be moved about from place to place, the operator not beingable to detect the presence of any solid constituent within the mass. 6. Absence of A)iy Tendency to Complete Their Dnrlopntenl.—Ofall signs of malignancy, this, in the case of sarcoma, is perhaps themost unequivocal. The cells do not complete the formation of con-nective tissue that normally they were destined to generate. Insteadof their energv being occupied in the metabolism necessan to secretethe matrix peculiar to each, it is wholly expended in the process ofreproduction. At certain stages in the process of repair the prolif-erated cellul
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