The Journal of biological chemistry . Fig. 4. the efficiency of the ventilation under it, a slight rise in alkalireserve being observed with vigorous ventilation by streaming airthrough the mask, and a slight fall when increased dead space,diminished oxygen tension, or increased CO2 tension are experiments with oxjgen are, however, not entirely con-sistent with the interpretation given above. The second inter-pretation is based upon the fact that if the variations in alkali Cullen, Austin, Kornblum, and Robinson 637. 638 Initial Acidosis in Anesthesia reserve in J-hese control expe


The Journal of biological chemistry . Fig. 4. the efficiency of the ventilation under it, a slight rise in alkalireserve being observed with vigorous ventilation by streaming airthrough the mask, and a slight fall when increased dead space,diminished oxygen tension, or increased CO2 tension are experiments with oxjgen are, however, not entirely con-sistent with the interpretation given above. The second inter-pretation is based upon the fact that if the variations in alkali Cullen, Austin, Kornblum, and Robinson 637. 638 Initial Acidosis in Anesthesia reserve in J-hese control experiments are plotted regardless of theparticular procedure adopted (see Fig. 6) it will be found thatthe changes distribute themselves in such a way that they mightbe interpreted as the fortuitous variations to be expected atrepeated bleedings. Whichever interpretation be preferred, wemay conclude that the control experiments indicate that the fac-tors taken into consideration do not produce at least individuallya change in alkali reserve greater than 5 mivi. Group III. {Experiments 6, 7, and 8; Fig. 7.) Nitrous Oxids —The effect of nitrous oxide whenadministered either pure or as 95 per cent nitrous oxide and 5per cent oxygen is shown in Experiments 6 and both these experiments it was found impossibleto secure anesthesia in the dog without using 95per cent or more of N2O. This inevitably led tomarked anoxemia. There occurred at first a risein total [CO2] in the serum associated in Experi-ment 6 with a


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Keywords: ., bookcentury1900, bookdecade1900, booksubjectbiochem, bookyear1905