. Carnegie Institution of Washington publication. THE CIRCULATION OF THE BONE-MARROW. 39 fat-space by these minute vessels. They are seen to lead directly from the large venous sinusoids by way of typical conical openings and appear to be continuous with them. This is illustrated in figure 3, which is an enlarged drawing of the portion of figure 2 indicated by the square. These vessels are not capillaries, in the sense of an arterio-venous transition, but extend from venous channel to venous channel; they are intersinusoidal. There is no break in the continuity of the endothelium which forms t
. Carnegie Institution of Washington publication. THE CIRCULATION OF THE BONE-MARROW. 39 fat-space by these minute vessels. They are seen to lead directly from the large venous sinusoids by way of typical conical openings and appear to be continuous with them. This is illustrated in figure 3, which is an enlarged drawing of the portion of figure 2 indicated by the square. These vessels are not capillaries, in the sense of an arterio-venous transition, but extend from venous channel to venous channel; they are intersinusoidal. There is no break in the continuity of the endothelium which forms these slender channels from sinusoid to sinusoid. There was no extravasation at any point and the material injected followed these vessels everywhere. It was quite evident that these channels were closed, in the sense that there was no extravasation or diffuse permeation of the tissues by the injected ink. The attempt to differentiate an extravasation from a true circumscribed distribution of perfused particles within definite channels was not made without a full appreciation of the marked tendency of such granules to follow a reticular framework closely in any injection into diffuse connective tissue. This character- — Ink mass in sinusoidal vessel. Endothelial nucleus , , i ,, Fig. 3.—A detail drawing of one of the typical conical open- Irwqranule in capillary . • . *fj .... r . ings from a venous sinusoid into the semi- collapsed lumen of an intersinusoidal capillary; indicated by insert in figure 2. nk mass. istic of reticular tissues to be outlined by extravasated particles, thus simulating, more or less closely, definite channels, is recognized and acknowledged, and it is obvious that the possibility of error of interpretation in injections of mesenchy- matous tissue requires a corresponding amount of attention and care in analysis. There were, however, five points apparent in the interpretation of these studies which emphasize strongly the non-fenestrated character
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