The Journal of laboratory and clinical medicine . ° C. with decomposition. It gives on analysis the fol-lowing percentage composition. gms. give N. at 24° C. and gms. give N. at ^ C. and gms. give gms. CO, and gms. gms. give gms. H.,0 and gms. CO,. Found Calculated for (QH,3Ne)3 (C,oH3N,0,) The substance agrees in composition with the picrolonate of trimethyl-melamine which is the polymer of methylcyanamide. The polymer was pre-pared from the synthetic methylcyanamide and found
The Journal of laboratory and clinical medicine . ° C. with decomposition. It gives on analysis the fol-lowing percentage composition. gms. give N. at 24° C. and gms. give N. at ^ C. and gms. give gms. CO, and gms. gms. give gms. H.,0 and gms. CO,. Found Calculated for (QH,3Ne)3 (C,oH3N,0,) The substance agrees in composition with the picrolonate of trimethyl-melamine which is the polymer of methylcyanamide. The polymer was pre-pared from the synthetic methylcyanamide and found to agree in reaction with A B N C H RECORD C. (See opposite page.) (Dog 2)Injection given by femoral â5 mgms. of synthetic substance per kilo body weight. Fall in pressure from injection 3 about 25 mm. Hg. Fall in pressure from injection 4 about 0 mm. Hg. Fall in pressure from injection 5 about 0 mm. Hg. Heart rate before injecting 108 per minute. Heart rate after injecting 108 per 310 The Journal of Laboratory and Clinical Medicine the natural substance. The picrolonate of the synthetic polymer was found tomelt at ° C. which, is slightly below the melting point of the natural discrepancy can be explained by the presence of small quantities of methyl-guanidin in the synthetic preparation which owing to the similarity in solubilityof the two picrolonates, could not be completely removed by fractional recrys-tallization. It was found that methylcyanamide polymerizes after a few daysstanding or several evaporations of its watery solution. Therefore the polymershould be expected in the urine from which the cyanamide was isolated. Because of the agreement in chemical and physiological properties (dis-cussed below) the substances may be considered identified as methylcyanamideand trimethylmelamine. Physiological Properties. The methylcvanamide isolated from the urines and the synthetic methyl-cyanam
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