. The Biological bulletin. Biology; Zoology; Biology; Marine Biology. 378 O. HOBERT AND G. RUVKUN signaling and that may also modulate downstream gene expression in behavioral plasticity (6). We have identified a second LIM homeobox gene, lin- II, that is expressed and functions in the opposing in- terneuron of the thermoregulatory circuit, AIZ (7). Hu- ll null mutant animals display cryophilic defects that phenocopy laser ablation of the AIZ interneuron. Al- though the lin-l 1 expressing neurons, including AIZ, are formed in lin-11 null mutant animals, they display neuro- anatomical defects,


. The Biological bulletin. Biology; Zoology; Biology; Marine Biology. 378 O. HOBERT AND G. RUVKUN signaling and that may also modulate downstream gene expression in behavioral plasticity (6). We have identified a second LIM homeobox gene, lin- II, that is expressed and functions in the opposing in- terneuron of the thermoregulatory circuit, AIZ (7). Hu- ll null mutant animals display cryophilic defects that phenocopy laser ablation of the AIZ interneuron. Al- though the lin-l 1 expressing neurons, including AIZ, are formed in lin-11 null mutant animals, they display neuro- anatomical defects, comparable to those neural defects observed in ttx-3 mutant animals. Like ttx-3, lin-ll ex- pression is also maintained in postmitotic neurons throughout adulthood. Thus, distinct LIM homeobox genes specify two functionally related antagonistic inter- neurons within a neural network dedicated for thermoreg- ulatory processes (see Fig. 2). How are thermoregulatory neural centers organized in more complex organisms? And is there any evidence for a conserved role for ttx-3 and lin-ll in the control of these neural centers? In fact, the organization of the C. elegans thermoregulatory network into two parallel, warm- and cold-processing pathways is remarkably simi- homtodomiiin temperature sensory input. ISLET-subclass LMX-subclass LHX3/4-subclass c-Lim-1 Xlim-1 zf-Lim-1 Xlim-5/Xlim-2 |_HX1/5-SUt>ClaSS zf-Lim-5 LIN-11 Dm-Bk87 MEC-J Dm-apterous >pt< h-LH-2 AP-subclass. Please note that these images are extracted from scanned page images that may have been digitally enhanced for readability - coloration and appearance of these illustrations may not perfectly resemble the original Marine Biological Laboratory (Woods Hole, Mass. ); Marine Biological Laboratory (Woods Hole, Mass. ). Annual report 1907/08-1952; Lillie, Frank Rattray, 1870-1947; Moore, Carl Richard, 1892-; Redfield, Alfred Clarence, 1890-1983. Woods Hole, Mass. : Marine Biological Laboratory


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Keywords: ., bookauthorlilliefrankrat, booksubjectbiology, booksubjectzoology