Diseases of metabolism and of Diseases of metabolism and of the blood, animal parasites, toxicology diseasesofmetabo00cabo Year: 1906 HEMOPHILIA 417 The fact that hemophilia may be directly transmitted also by the ?nale descendants forms an exception to the rule that women, even healthy women, transmit the disease, that is, act as conductors. In a family in Bremen the affection was transmitted by the father to the male members through three generations. Also in the bleeder family from Wald in the Canton Zurich such a tendency is noted, while on the other hand, the transmission from the healt
Diseases of metabolism and of Diseases of metabolism and of the blood, animal parasites, toxicology diseasesofmetabo00cabo Year: 1906 HEMOPHILIA 417 The fact that hemophilia may be directly transmitted also by the ?nale descendants forms an exception to the rule that women, even healthy women, transmit the disease, that is, act as conductors. In a family in Bremen the affection was transmitted by the father to the male members through three generations. Also in the bleeder family from Wald in the Canton Zurich such a tendency is noted, while on the other hand, the transmission from the healthy mother occurs in the sons. In this case, in the first generation that showed bleeders, among 16 persons there were 7 bleeders. In the following generation, among 28 members there were 16 bleeders. In the third genera- tion, there was a noteworthy decrease in that this showed only 1 bleeder and + + Fig. 23.—Genealogical Tree of a Bleeder Family. (After II. Gocht.) Bleeders are shaded. 12 non-bleeders. That from a hemophilic mother bleeders as well as non- bleeders may be born is demonstrated by the following ancestral tree which is taken from a communication of H. Gocht (Anh. f. Min. Chir., Bd. 59) (Fig. 23). The disease proved itself most stubborn in a family in the little village of Tenna in Graubündten, consisting of aboul 170 persons, whose family tree was firai described by Grandidier and Vieli, and then carefully revised by Eösli who eliminate«! many incorreel statements of the firsl communication. Eere the hereditary transmission could be followed through sis or seven gen- erations. However, bleeders twice married into the family, which may explain the long persistence of the pathologic predisposition. Several times the dis- ease skipped two generations in this family, then reappeared in the third. In the direct descendancy -till longer pauses occurred; but probably only the severesl cases have been recorded. The disturbances to which we may ascribe hemophilia
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