. Ciba Foundation Symposium on Transplantation. Transplantation of organs, tissues, etc. 344 DISCUSSION lethal runting, with almost half of the injected animals having a decrease in their weight curve, while animals injected with normal isologous cells have no decrease in weight. It seems difficult to escape the con- clusion that under these experimental conditions the spleen cell popu- lation of a tolerant animal reacts in a way which is closer to the way in which immunized spleen cells react than to the way normal spleen cells Rejection Reaction. Homologous cells Injected Fig. I (Voisin). Di
. Ciba Foundation Symposium on Transplantation. Transplantation of organs, tissues, etc. 344 DISCUSSION lethal runting, with almost half of the injected animals having a decrease in their weight curve, while animals injected with normal isologous cells have no decrease in weight. It seems difficult to escape the con- clusion that under these experimental conditions the spleen cell popu- lation of a tolerant animal reacts in a way which is closer to the way in which immunized spleen cells react than to the way normal spleen cells Rejection Reaction. Homologous cells Injected Fig. I (Voisin). Diagrammatic representation of the proposed hypothesis. General scheme: the intensity of the respective reactions (arrows) will lead to the possibihties represented in the following figures. react. And this seems to me to be extremely important, especially in view of our working hypothesis of recent years which is concerned with the relationships between specific acquired tolerance to hving cells, runt disease and enhancement phenomenon. This working hypothesis is diagrammatically represented in Fig. i. When an injection of immunologically competent cells is made intra- venously into a homologous newborn mouse, the subsequent immuno- logical phenomena will evolve in two consecutive phases depending on the state of immunological maturation of the young Please note that these images are extracted from scanned page images that may have been digitally enhanced for readability - coloration and appearance of these illustrations may not perfectly resemble the original Ciba Foundation Symposium on Transplantation (1961 : London, England); Wolstenholme, G. E. W. (Gordon Ethelbert Ward); Cameron, Margaret P. Boston, Little, Brown
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