. A treatise on Asiatic cholera. wliich had a special a])pearance with regard to size and sliape, so thatone could distinguish them from other bacteria, ami devote special attention tothem, various other bacteria had forced their way into the utricular glands andthe surroundin-tissue, e. g., large thick bacilli and veiy tiiin bacilli. Thereby THE DOCTRINE OF KOCH. ^53 conditions are produced similar to those in necrotic diphtlieritic changes of themucous membrane^ of tlie intestine, and in typhoid ulcers, where afterward othernon-patliogenic bacteria force their way into the tissue rendered ne
. A treatise on Asiatic cholera. wliich had a special a])pearance with regard to size and sliape, so thatone could distinguish them from other bacteria, ami devote special attention tothem, various other bacteria had forced their way into the utricular glands andthe surroundin-tissue, e. g., large thick bacilli and veiy tiiin bacilli. Thereby THE DOCTRINE OF KOCH. ^53 conditions are produced similar to those in necrotic diphtlieritic changes of themucous membrane^ of tlie intestine, and in typhoid ulcers, where afterward othernon-patliogenic bacteria force their way into the tissue rendered necrotic by bacteria. We were, therefore, from tlie very beginnin,t;-, oblig-ed to lookupon these first-mentioned bacteria as not altogether vmimportant for the cholera-process, while the other changes gave the impression of being secondarj; for thebacteria first described always advanced beyond the others, they forced their wayfarther in, and gave tlie impression as if they had smoothed the way for the ? T» tt Fig. 1.—Section of the mucous membrane of a cholera-intestine. A utricular gland (Vo is diag-onally cut through. In its interior (6), and between the epithelium and basement-membrane (,c)nimierous comma-bacilli. 600 magnifying power. With regard to the contents of the intestine, at first no clear idea could beformed, as the only cases which came before us for examination were not suitable;in these, also, the contents of the intestine were already putrid and bloody. Anenormous quantity of various bacteria was found in these contents, so thatthere was no possibility of attending to the real cholera-bacilli. Not till Ihad dissected a number of acute and vmcomplicated cases, in which no htcmor-rhage had as yet set in, and in which the contents of the intestines had not yetundergone putrid decomposition, did I recognize that, the puier and fresher thecases, the more did a special kind of bacteria prevail in the contents of the intes-tines. It was
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