. University of Toronto studies. Physiological series. no. 1-98. 1900-28 . , xxxvii, 384) perfiLsed the limb of a dog,with the nerves intact. Adrenal extract was injected into the jugular vein andthe volume change in the limb was studied by the venous outflow. He usuallyobtained no change in the flow but occasionally there was a small decrease in theoutflow. This was believed to be due to the escape of adrenal extract into thelimb because the decrease was not synchronous with the rise in blood pressure; infact the pressure had returned to normal before the limb changed. .52] 522 F. A. HARTMAN,
. University of Toronto studies. Physiological series. no. 1-98. 1900-28 . , xxxvii, 384) perfiLsed the limb of a dog,with the nerves intact. Adrenal extract was injected into the jugular vein andthe volume change in the limb was studied by the venous outflow. He usuallyobtained no change in the flow but occasionally there was a small decrease in theoutflow. This was believed to be due to the escape of adrenal extract into thelimb because the decrease was not synchronous with the rise in blood pressure; infact the pressure had returned to normal before the limb changed. .52] 522 F. A. HARTMAN, L. G. KILBORN AND LOIS FRASER alin to them. In the first, a 1: 100,000 adrenaUn solution producedonly dilatation while a 1: 10,000 solution caused steady marked con-striction. In the other a 1:1,000 solution caused a dilatation followedby constriction. Three animals gave no constriction. The first (a cat)was tried by dropping adrenalin upon the sympathetic ganglia. On thelast two (dogs) the dorsal root ganglia had been removed, adrenalin beinggiven by the jugular Fig. 1. Constriction and dilatation of a perfused limb from the injection of 4CO. adrenalin, 1: 5,000 into the jugular vein. All sympathetic ganglia supplyingthe limb had been destroyed. Dog kgm. Reduced 5. From dorsal root ganglia. Of the animals (seven dogs) in which thesympathetic ganglia to the perfused hind limb had been destroyed, onlyone responded by constriction when adrenalin was injected into thegeneral circulation (fig. 1). Direct application of adrenalin to the dor-sal root ganglia in one of two cats caused constriction in the hind limb(fig. 2). In almost all of the animals studied whether giving gangliarconstriction or not, dilatation from adrenalin was obtained. VASCULAR RESPONSE OF ADRENALIN ON NERVE GANGLIA 523 We may say, in general for the hind limb, that the effect of adrenalinon the ganglia is preeminently dilator and that the constriction fromthis source is insignificant. Constriction
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