Clinical diagnosis : the bacteriological, chemical, and microscopical evidence of disease . ointinfection produced by the co-operative action of the typhoid bacillusand Bacterium coli commune. In conclusion, it may be remarked that, in addition, a certain prog-nostic importance must be attributed to the Widal test, the degree ofinfection, and therefore, in all probability, the severity of the diseaseincreasing in proportion with the ratio of dilution (1: 100, 1: 800, 1: 1000)under which the blood continues to furnish the reaction. COLOURING MATTER OF BLOOD 73 VII. CHEMICAL CHANGES IN THE BLOOD


Clinical diagnosis : the bacteriological, chemical, and microscopical evidence of disease . ointinfection produced by the co-operative action of the typhoid bacillusand Bacterium coli commune. In conclusion, it may be remarked that, in addition, a certain prog-nostic importance must be attributed to the Widal test, the degree ofinfection, and therefore, in all probability, the severity of the diseaseincreasing in proportion with the ratio of dilution (1: 100, 1: 800, 1: 1000)under which the blood continues to furnish the reaction. COLOURING MATTER OF BLOOD 73 VII. CHEMICAL CHANGES IN THE BLOOD. 1. Colouring —The most important constituent of theblood is the Oxyhemoglobin—the combination of the colouring matterwith oxygen which is formed by the aeration of the blood in the characteristic spectrum of dilute solutions of this body exhibits twoabsorption-bands between D and E (of Fraunhofers lines). The bandnearest to D is darker, narrower, and more strongly marked; that nextto E is less sharply denned and broader (fig. 37). Bed. Orange. Yellow. Fig. 37.—Spectrum of Oxyhemoglobin. When submitted to the action of deoxidising substances, oxyhaemo-globin gives place to Reduced Haemoglobin. The spectrum of this bodyis characterised by a single band, occupying a space about midway be-tween the former two bands (fig. 38). Under the action of acids of all kinds, of strong alkalies, and even ofC02, haemoglobin is broken up into (1) a proteid resembling globulin,and (2) the iron-containing body known as Hsematin. The spectrum of hasmatin in alkaline solution shows an absorption- Red. Orange. Yellow. Green. Cyanhlue. A a B C D El> F 40 50 60 70 80 90 100 110 lllllililimhinllllll


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Keywords: ., boo, bookcentury1800, bookdecade1890, booksubjectclinicalmedicine