The Journal of laboratory and clinical medicine . which the air or gases, including the exhaled COo from the patientare washed. The CO, is immediately absorbed by the sodium hydrate formingsodium carbonate and water according to the following equation: 2 Xa OH -f CO, = Xa, CO3 -f H,0. The sodium carbonate being a soluble salt of course remains in solution (to- *From the Department of Phaimacology of Washington University Medical School, St. Louis, Mc The Pharmacological Action of Nitrous Oxide 645 gether with the formed) in the jar, the COo being thus removed from theair (or nitrous oxide
The Journal of laboratory and clinical medicine . which the air or gases, including the exhaled COo from the patientare washed. The CO, is immediately absorbed by the sodium hydrate formingsodium carbonate and water according to the following equation: 2 Xa OH -f CO, = Xa, CO3 -f H,0. The sodium carbonate being a soluble salt of course remains in solution (to- *From the Department of Phaimacology of Washington University Medical School, St. Louis, Mc The Pharmacological Action of Nitrous Oxide 645 gether with the formed) in the jar, the COo being thus removed from theair (or nitrous oxide and oxygen) which the animal breathes. During this proc-ess the oxygen is consumed (250 to 300 per minute for an adult man at rest)by the animal or patient. More oxygen is injected into the system from timeto time in just such quantities as the animal actually consumes. The nitrous•oxide, being a stable gas, is not broken down at all either by the animal or bythe acid or sodium hydrate. Consequently there need be but little waste of the. Fig. 1-—Nitrous oxide appaiatus wilh large bag as used for experimeiUal purposes. (Ior discussion, see text.) NoO and only a small amount ( c\|HTinicnlally 1 have estimated that from 1^/2to 3 gallons will be necessary for a man weighing 1()0 pounds) is rc(iuired tosaturate the blood sufficiently to produce anesthesia, \\hen a given amount ofNoO is injected into the closed system juid breathing bag. the animal, whose lungsvirtually form a part of tlie closed system, will at once begin to absorb NoO intoits blood from ihr pulmonary alveolar walls. This absorption goes on unlil anequilibrium in the quantity of contained in tlie animals blood and tissueson the one side and that contained in thr breathing batr and tubes on the other 646 The Journal of Laboratory and Clinical Medicine is established. It is important, however, to remember in this connection thatthe affinity of the blood and presumably of the central nervous system is grea
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