. General surgical pathology and therapeutics, in fifty-one lectures .. . uld be formed. Fortu-nately, this is never or very rarely the case. You already know, fromthe representation of the external conditions, that when the granula-tions have reached the level of the cutis, or even sooner, they ceaseto grow and are coated with epidermis, and retrograde to a following changes occur in the tissue : At first, in the granula-tion tissue, as in the edges of the wound in healing by the first inten-tion, there are numerous cells which are destroyed. Not only themillions of pus-cells on
. General surgical pathology and therapeutics, in fifty-one lectures .. . uld be formed. Fortu-nately, this is never or very rarely the case. You already know, fromthe representation of the external conditions, that when the granula-tions have reached the level of the cutis, or even sooner, they ceaseto grow and are coated with epidermis, and retrograde to a following changes occur in the tissue : At first, in the granula-tion tissue, as in the edges of the wound in healing by the first inten-tion, there are numerous cells which are destroyed. Not only themillions of pus-cells on the surface, but also cells in the depths of thegranulation tissue, disappear by disintegration and reabsorption ; it isvery probable that cells from the granulation tissue may pass back un-injured into the vessels, as we shall see when treating of the organi-zation of thromboses of the vessels. As the cells retrograde, fine fat-granules gradually form in them, not only in the round but also inthe spindle-shaped ones; such cells, which are composed of very fine Pig. Diagram of granulation of a wound ; the layer of pus-cells is represented as having been actedon by acetic acid, to distinguish the pus-cells in the figure more accurately from the granu-lation cells. Magnified 300-400 diameters. 78 SIMPLE INCISED WOTTXDS OF THE SOFT PARTS. fat-globules, are generally called granular cells (Kornchenzellen) ; theyoften occur in the granulations, as above described. When the gran-ulation tissue is thus diminished by atrophy and escape of the cells,and at the same time the new formation of cells ceases, something im- FlG.
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