. Ciba Foundation colloquia on ageing. Old age; Aging; Animals -- growth & development. ORGAN CULTURE STUDIES OF FOETAL RA REPRODUCTIVE TRACTS Dorothy Price and Richard Pannabecker Zoology Department, University of Chicago In rodents, the question of the role of endogenous sex hormones in the retention or loss of Wolffian ducts and Mul- lerian ducts and in the formation of the primordia of accessory reproductive glands has not been completely answered.* The problem has been investigated chiefly by 1) administra- tion of sex hormones to pregnant females (the most extensive researches are th
. Ciba Foundation colloquia on ageing. Old age; Aging; Animals -- growth & development. ORGAN CULTURE STUDIES OF FOETAL RA REPRODUCTIVE TRACTS Dorothy Price and Richard Pannabecker Zoology Department, University of Chicago In rodents, the question of the role of endogenous sex hormones in the retention or loss of Wolffian ducts and Mul- lerian ducts and in the formation of the primordia of accessory reproductive glands has not been completely answered.* The problem has been investigated chiefly by 1) administra- tion of sex hormones to pregnant females (the most extensive researches are those of Raynaud, 1942; Greene and his col- laborators, reviewed by Greene, 1942); 2) transplantation of foetal reproductive tracts into postnatal hosts (Moore and Price, 1942); 3) foetal gonadectomy by X-ray (Raynaud and Frilley, 1946, 1947, 1950; Raynaud, 1950) and by surgical castration (Wells and Fralick, 1951; Wells, Cavanaugh and Maxwell, 1954). Organ culture offered a technique for further analysis of the problem by isolation of foetal reproductive tracts from other foetal endocrine organs in an environment free from maternal and placental hormones, and under conditions in which the gonads could be removed with a minimum of traumatic injury. It was recognized that, if sex hormones were present in the testes or ovaries, diffusion might be expected since this has been demonstrated for foetal rat testes (Jost, 1948; Jost and Colonge, 1949; Moore, 1953). Methods The methods will be described in detail elsewhere (Panna- becker, 1956). In brief, about three hundred foetal rat * Many of the problems of sex differentiation in the rabbit, a member of the Lagomorpha, have been clarified by the research of Prof. Jost. 3. Please note that these images are extracted from scanned page images that may have been digitally enhanced for readability - coloration and appearance of these illustrations may not perfectly resemble the original Ciba Foundation; Wolstenholme, G. E. W. (Gordo
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