. Cellular basis and aetiology of late somatic effects of ionization radiation. Radiation -- Physiological effect. 292 A. C. UPTON, M. A. KASTENBAUM, AND J. W. CONKLIN was evident. For other types of leiilvaemia (Fig. 11), and ovarian (Fig. 12) and pulmonary (Fig. 13) tumours, the curves more nearly resembled those of the over-all population (Figs. 1-4). too. 450 600 Age (days) 1050 Fig. 13. Age-specific mortality rate of RF female mice dying with pulmonary tumour, as influenced by X-rays, TEM, or HN2 administered early in life (arrow denotes age at treatment). See Methods for doses. O Untreat
. Cellular basis and aetiology of late somatic effects of ionization radiation. Radiation -- Physiological effect. 292 A. C. UPTON, M. A. KASTENBAUM, AND J. W. CONKLIN was evident. For other types of leiilvaemia (Fig. 11), and ovarian (Fig. 12) and pulmonary (Fig. 13) tumours, the curves more nearly resembled those of the over-all population (Figs. 1-4). too. 450 600 Age (days) 1050 Fig. 13. Age-specific mortality rate of RF female mice dying with pulmonary tumour, as influenced by X-rays, TEM, or HN2 administered early in life (arrow denotes age at treatment). See Methods for doses. O Untreated control (26/130 mice); • HN2 (94/160 mice); A TEM (82/157 mice); Q X-ra,y (12/259 mice). DISCUSSION From these results, it is evident that the life-shortening effect of irradiation in the mouse is correlated with early mortality from non-neoplastic, as well as neoplastic diseases, many of which are otherwise associated with senescence. The non-neoplastic diseases include nephrosclerosis, cardiac thrombosis, enteritis, intussusception, and diverse inflammatory and degenerative changes (see Upton et at, 1960), the pathogenesis and significance of which require further study. The incidence of all neoplasms increased with age, except for thymic lymphomas and myeloid leukaemias, which reached a peak at early ages in irradiated animals. The basis for the early induction of radiogenic leukaemias remains to be disclosed, but the possibility that it may be related to viral aetiological factors must be considered. Whether or not the relatively short induction period of radiogenic leukaemia in man (see Upton, 1961) reflects a situation analogous to that in the mouse cannot be decided without further Please note that these images are extracted from scanned page images that may have been digitally enhanced for readability - coloration and appearance of these illustrations may not perfectly resemble the original Harris, R. J. C. (Robert John Cecil), 1922-; Unesco; I
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