. Biology of the laboratory mouse. Mice as laboratory animals; Mice; Animals, Laboratory; Mice. THE GENETICS OF TUMOR TRANSPLANTATION >87 The most important and critical scries of crosses were tliose in which tumor 13714BX, originating in an Fi generation mouse, was used for transplantation. This tumor, inoculated in F2 generation mice gave 94+:25o—. This indicated that either 4 or 5 genes were involved. The experimental results lie between the expectation for this number of genes and afford no basis for choice as to the exact Fig. 130.—Diagram showing the relationship existing bet
. Biology of the laboratory mouse. Mice as laboratory animals; Mice; Animals, Laboratory; Mice. THE GENETICS OF TUMOR TRANSPLANTATION >87 The most important and critical scries of crosses were tliose in which tumor 13714BX, originating in an Fi generation mouse, was used for transplantation. This tumor, inoculated in F2 generation mice gave 94+:25o—. This indicated that either 4 or 5 genes were involved. The experimental results lie between the expectation for this number of genes and afford no basis for choice as to the exact Fig. 130.—Diagram showing the relationship existing between the various stocks and generations of mice employed by Bittner in studies of transplantable tumors arising in hybrid mice. The two parent strains are called "A" (albino) and "D" (dba or dilute brown). Two arrows pointing towards a square indicate that the particular generation was produced by crossing the two stocks or generations from which the arrows come. One arrow indicates that the matings were inter se to produce the next generation. {From Bittner.) The most interesting figures come, however, from the two backcross generations, that of Fi X A (ZBC) and that of Fi X D (iBC). The actual figures, compared with expectation for various numbers of genes which are introduced by the respective parent stocks, are shown in Table 8. It appears, therefore, that probably four or five pairs of genes, of which one or two are introduced by the A stock and three or four are introduced by the D stock, are involved. The fact that the evidence provided by the backcross generations sup- ports the probability that four or five genes are involved, is Please note that these images are extracted from scanned page images that may have been digitally enhanced for readability - coloration and appearance of these illustrations may not perfectly resemble the original Roscoe B. Jackson Memorial Laboratory; Little, Clarence C. (Clarence Cook), b. 1888; Sne
Size: 1754px × 1425px
Photo credit: © Library Book Collection / Alamy / Afripics
License: Licensed
Model Released: No
Keywords: ., boo, bookcentury1900, bookcollectionbiodiversity, booksubjectmice
