. The Biological bulletin. Biology; Zoology; Biology; Marine Biology. EFFECTS OF NITROGEN MUSTARDS 273 220 180 140 O z UJ CJ O 80 40. TfME IN HOURS FIGURE 3. The effect of MBA ( M) on the respiration of dilute sperm suspensions. Dilution, 1:200. Qo2 = ; 1. Control; 2. MBA. actively moving pluteus (45 per cent) while the eggs receiving treated sperm had only 8 per cent of motile pluteus and had 16 per cent of cells morphologically abnormal. Delay in the rate of cell cleavage, decrease in the number of cells reaching the pluteus stage, as well as abnormal cells, were found even when spe
. The Biological bulletin. Biology; Zoology; Biology; Marine Biology. EFFECTS OF NITROGEN MUSTARDS 273 220 180 140 O z UJ CJ O 80 40. TfME IN HOURS FIGURE 3. The effect of MBA ( M) on the respiration of dilute sperm suspensions. Dilution, 1:200. Qo2 = ; 1. Control; 2. MBA. actively moving pluteus (45 per cent) while the eggs receiving treated sperm had only 8 per cent of motile pluteus and had 16 per cent of cells morphologically abnormal. Delay in the rate of cell cleavage, decrease in the number of cells reaching the pluteus stage, as well as abnormal cells, were found even when sperm and MBA were in contact for only two minutes before fertilization. DISCUSSION The sperm of sea urchin is a striking exception in its response to the addition of nitrogen mustards. While other cells or tissues are either inhibited or not af- fected in their respiration, the sperm of sea urchin showed a marked increase. This increase, which comprises the whole respiration process there being no alteration in the respiratory quotient, must be due to the action of nitrogen mustards on the regulatory mechanisms of the cell, , those mechanisms which control the equi- librium relationships between anabolic and catabolic processes. The increase in respiration seems to occur, however, only when small concentrations of nitrogen mustard penetrate into the cells, for when the cell concentration was decreased com- plete inhibition of respiration followed the initial stimulation. Undoubtedly, as more nitrogen mustard penetrated the cells a concentration was reached—enough to produce the known enzyme inhibitions found by Cori (1943), Dixon (1942) and Barren et al. (In press). The stimulation of respiration might be due to. Please note that these images are extracted from scanned page images that may have been digitally enhanced for readability - coloration and appearance of these illustrations may not perfectly resemble the original Marine Biological Laboratory (Woods Hole, Ma
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Keywords: ., bookauthorlilliefrankrat, booksubjectbiology, booksubjectzoology
