Increased local substrate concentrations in enzyme-DNA nanostructures as a result of engineered substrate-DNA interactions. Left: The DNA structures used here to investigate the effects of substrate-DNA binding interactions on enzyme catalysis. Colored strands are indicative of sequence. Right: Representation of enzyme-DNA nanostructures with a double-crossover DNA tile chemically conjugated to an HRP. The mechanism of increased local substrate concentration and enhanced catalysis is shown schematically: binding interactions between enzyme substrates and the DNA scaffold result in increased lo
Increased local substrate concentrations in enzyme-DNA nanostructures as a result of engineered substrate-DNA interactions. Left: The DNA structures used here to investigate the effects of substrate-DNA binding interactions on enzyme catalysis. Colored strands are indicative of sequence. Right: Representation of enzyme-DNA nanostructures with a double-crossover DNA tile chemically conjugated to an HRP. The mechanism of increased local substrate concentration and enhanced catalysis is shown schematically: binding interactions between enzyme substrates and the DNA scaffold result in increased local concentrations of substrate, giving rise to a decrease in apparent Michaelis-Menten constant (KM) and a corresponding increase in enzyme efficiency (kcat/KM).
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Keywords: agencys, biological, brian, cb, chembiochem, chemical, compounts, countermeasure, defense, department, development, dna, dtra, molecule, nanomaterials, pate, penetration, , portfolio, reduction, scavenging, small, techno, technologies, threat, toxicant, tps
