Practical physiological chemistry; a book designed for use in courses in practical physiological chemistry in schools of medicine and of science . very variation occurs, both in time ofevacuation as well as the character of the curve and the quantity of thesecretion elaborated. Fig. 41 represents some of the possibilities ofpathological cases, but a consideration of their interpretation is outsidethe purpose of the present volume. It will be evident, however, froma consideration of the figure that the cycle of gastric digestion is a con-stantly changing one, and no information concerning the t
Practical physiological chemistry; a book designed for use in courses in practical physiological chemistry in schools of medicine and of science . very variation occurs, both in time ofevacuation as well as the character of the curve and the quantity of thesecretion elaborated. Fig. 41 represents some of the possibilities ofpathological cases, but a consideration of their interpretation is outsidethe purpose of the present volume. It will be evident, however, froma consideration of the figure that the cycle of gastric digestion is a con-stantly changing one, and no information concerning the trend ofdigestion can be obtained by an examination of only a single stage ofdigestion. Marked changes may precede or follow that stage and thepossibilities suggested in Fig. 41 are all observed clinically and are ofvarying significance. Typical curves from cases of hyperacidity,gastric carcinoma and achylia are shown in Figs. 46, 47 and 48respectively. 164 PHYSIOLOGICAL CHEMISTRY (b) Determination of Free Acidity.—The reagent most widely used,clinically, for the determination of free hydrochloric acid in stomach 100 Total acidih| x:o to o. Free acidity A V/z IV4. 2 hours Fig. 46.—Acidity Curves From a Case of Hyperacidity. contents is Topfers reagent (see page 175). It has been found, however,that this reagent gives rather inaccurate results due to the uncertain c I 1 1120960 800^ u 640§toz 480^ 320 80 60 160 40 1 1 i ( <itriccinon a i i •§ 1 4 / / / y y ^ ^^ ilac ^^ y ^_,..^- Iic ,^ Fre Fig. 47.—Acidity and Protein Curves in Gastric Am. Med. Assn, 64, 1737, 1915-) (Clarke and Rehfuss: end point. For this reason we have employed Sahlis reagent.^ Thisreagent contains KI and KIO3 and liberates iodine in the presence of ^ A mixture of equal parts of a 48 per cent solution of potassium iodide and an 8 per centsolution of potassium iodate. GASTRIC ANALYSIS 165 free hydrochloric acid. The liberated iodine is titrated by thiosulphateusing starch as a
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