Manual of pathology : including bacteriology, the technic of postmortems, and methods of pathologic research . eriphery of theer>throcytes, and from the points where these arcs meet, faint lines areprojected toward the centrally collected mass of jiigment. As this stageis completed the parasite is divided into fifteen or twenty oval or pyn-form segments, the apices of which are directed toward the inactivepigment in the center. As now seen, the remains of the swollen eryth-rocyte are indistinct and the radiating spores present the characteristicrosette or daisv form. With the completion of


Manual of pathology : including bacteriology, the technic of postmortems, and methods of pathologic research . eriphery of theer>throcytes, and from the points where these arcs meet, faint lines areprojected toward the centrally collected mass of jiigment. As this stageis completed the parasite is divided into fifteen or twenty oval or pyn-form segments, the apices of which are directed toward the inactivepigment in the center. As now seen, the remains of the swollen eryth-rocyte are indistinct and the radiating spores present the characteristicrosette or daisv form. With the completion of sporulation the red cellscontaining the parasites rupture, the liberated young plasmodia are freedin the blood-plasma and at once enter red cells. The liberated pigmentis taken up by the phagocytes, particularly the leukocytes, but also byphagoc^-tic endothelial cells. A careful examination of the blood will show that in a numl^r ofthe infected red cells sporulation does not occur, and that in an earlierstage in the evolution of the parasite it escapes from the host cell. I his GENERAL PATHOLOGY. 12 A B. Fig. ioi.—Diagrammatic Representation of the Life Cycle of the Plasmodium —(Modified and redrawn ajter Clarke.)[The letters refer to the stages of schizogony and the figures to sporogony.] A. Hyaline intracorpuscular body called by Lankaster the amebula, the earUest stage of the parasite \\-ithin the red cell. B. Later stage of A, showing beginning formation of pigment. A and B are stages in the growth of the merozoite, and with C constitute the changes in the schizont during the process of schizogony. C. Sporulating intracellular parasite; daisy or rosette form; pigment in center. D. Ruptured cell hberating sporules or merozoites,some of which return to red cells, as indicated bv the arrow, and repeat this process of schizogony or multipUcadve reproduction. Other merozoites after intermediary stagesdevelop into gametes. 1. Microgametocyte or male element. 2. Macro


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