. Electrolytes in biological systems, incorporating papers presented at a symposium at the Marine Biological Laboratory in Woods Hole, Massachusetts, on September 8, 1954 . Fig. 6. K"*" leakage by yeast into a K^-free medium as a function of pH, with and without lucose. pointed out that at pn a steady state exists at 5 X io~* m/1. K+, in which the leakage rate is equal to the rate of inflow. The leakage rate is about 12 mivi/kg hr. of cells. Thus the rate of inflow must be at least 12 mn/kg hr. at this re- markably low concentration of K"*". At higher concentrations of
. Electrolytes in biological systems, incorporating papers presented at a symposium at the Marine Biological Laboratory in Woods Hole, Massachusetts, on September 8, 1954 . Fig. 6. K"*" leakage by yeast into a K^-free medium as a function of pH, with and without lucose. pointed out that at pn a steady state exists at 5 X io~* m/1. K+, in which the leakage rate is equal to the rate of inflow. The leakage rate is about 12 mivi/kg hr. of cells. Thus the rate of inflow must be at least 12 mn/kg hr. at this re- markably low concentration of K"*". At higher concentrations of K+ the rate of inflow approaches 360 mM/kg hr. The actual rates of inflow may be even higher, because in addition to correcting for the outflow of K+ measured by leakage into a K+-free medium there may be an additional correction for outflow of K+ associated with a K+-K+ exchange when the medium contains appreciable concentrations of K+. The extent of the latter phenomenon can be determined by isotope studies. The relationship between K+ concentration and K+ inflow appears to follow an asymptotic curve on the basis of preliminary data, with one half maximal rate at a K+ concentration of about 3 X io~^ m/1. However, a great deal more experimental data on rates of inflow and outflow are required
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