Medical bulletin . vasodilatation. The length of time required for theonset of symptoms does not differ materially for the differentdrugs or for doses of different size, so long as the dose is a toxicone. There is, however, some difference noted for each of thesefactors in the rate of recovery. After doses just sufficient toproduce the phenomena described complete recovery seldomtakes over five minutes, but when the doses are nearly fatal thetime of recovery may be about doubled, repeated clonic con- OF ANKSTHKTKS 441 vulsions beiii«:: coiitiiiiied for from six to ten l
Medical bulletin . vasodilatation. The length of time required for theonset of symptoms does not differ materially for the differentdrugs or for doses of different size, so long as the dose is a toxicone. There is, however, some difference noted for each of thesefactors in the rate of recovery. After doses just sufficient toproduce the phenomena described complete recovery seldomtakes over five minutes, but when the doses are nearly fatal thetime of recovery may be about doubled, repeated clonic con- OF ANKSTHKTKS 441 vulsions beiii«:: coiitiiiiied for from six to ten luinutes after theinjection. The <litterent <lrn<is, also, may he <livide<l into two<j;roni)s with reference to the rate of recovery foUowinj; a sin«|;lesnhlethal dose. Cocain and liolocain are the only members ofthe tirst jironp, and are characterizes! hy a ihMich^Uy more pro-lonp,ed action than is seen after any of the other cocain sub-stitntes. This difference will be more dearly shown when we. Fig. 1 come to the discnssion of re])eated doses, and it is one of primeimportance. The second ^ronp comprises all the other drugsstudieil; which sho^y only slight differences in the rates of re-covery, and from all of which recovery is rapid. The effects upon the lieart and circulation, upon the respira-tion, and the rapid recovery from these etfects, are shown in thetracing—figure 1 which accompanies the following protocol. 442 GARY EGGLESTON AND ROBEKT A. HATCHER Frofocol 1. Cat, male, .!ffJ Iryin. Twenty milligrams x kgm. uirvanin in 10 per cent solution at onceinto femoral vein. Sharp fall of blood pressure in less than ten sec-onds, followed at once by respiratory stimulation. Then respirationalmost stopped, while heart liegan to show slight recovery. Withintwo minutes after the injection the blood pressure had returned tonormal. Clonic convulsions interfered with the respiratory tracing. Recovery was complete in less than ten minutes; when a surely fatal
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