. Diseases of infancy and childhood . nters and causes disturbances in the gastro-intestinaltract seems very plausible; thus, food contaminated has been regarded as aprobable source of trouble. Just where the specific micro-organism entersthe human system is not yet clearly defined, although the nasopharynxappears to be the place where the infection takes place. ^Journal of Experimental Medicine, vol. xviii, No. 4, 1913. INFANTILE SPINAL PARALYSIS. 769 Childhood is the age most susceptible to an infection of the New York epidemic of 1907^ out of 729 cases studied, 221 occurred
. Diseases of infancy and childhood . nters and causes disturbances in the gastro-intestinaltract seems very plausible; thus, food contaminated has been regarded as aprobable source of trouble. Just where the specific micro-organism entersthe human system is not yet clearly defined, although the nasopharynxappears to be the place where the infection takes place. ^Journal of Experimental Medicine, vol. xviii, No. 4, 1913. INFANTILE SPINAL PARALYSIS. 769 Childhood is the age most susceptible to an infection of the New York epidemic of 1907^ out of 729 cases studied, 221 occurredbetween the ages of 1 and 2 years, 180 between 2 and 3 years, lOG between3 and 4 years, 63 between 4 and 5 years, and 62 under 1 year of age. Thesummer seems to be favored with more cases than any other season of theyear. Pathology.—^One of the facts now established is that the inflammationof the cord is always accompanied by an inflammatory process in the piamater. The pathological process in the cord itself is primarily dependent. —<35 Fig. 258.—Poliomyelitis. Sclerosis and cicatricial atrophy of the leftanterior horn of the fourth cervical nerve after acute anterior poliomyelitis.(a) Normal anterior horn with ganglion cells. (&) Atrophic anterior horn.(Ziegler.) upon vascular changes, and secondarily, upon changes in the cells, bothganglionic and interstitial. The vessels of the cord, medulla, pons, basalganglia, and even the cerebral cortex are dilated and engorged, and in thecord, medulla, and pons the capillaries are distended to more than twicetheir normal caliber. This hyperamiia is found at all levels of the cordirrespective of the intensity of the other inflanunatoiy changes. It is nowfirmly established that the pathological process in acute poliomyelitis is onewhich is primarily dependent upon the vascular and interstitial tissuechanges and that the ganglion cells are secondarily affected. The ganglioncells most affected are those in the anteiitu- horn of th
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