. Adventures in radioisotope research;. Radioactive tracers; Radiobiology. ISOTOPIC INDICATORS IN HAEMATOLOGY 649 In contrast to the globulin iron, the non-physiologically bound iron has been shown by electrophoretic studies to pass into the intercellular space essentially free from transferrin, as shown in Fig. 9; this diagram shows the distribution of non-physiologically bound iron introduced into the plasma, in the intercellular space and the cellular space of a normal rabbit. The problems mentioned in the introduction can be solved in other, though more tedious ways, by applying isoto
. Adventures in radioisotope research;. Radioactive tracers; Radiobiology. ISOTOPIC INDICATORS IN HAEMATOLOGY 649 In contrast to the globulin iron, the non-physiologically bound iron has been shown by electrophoretic studies to pass into the intercellular space essentially free from transferrin, as shown in Fig. 9; this diagram shows the distribution of non-physiologically bound iron introduced into the plasma, in the intercellular space and the cellular space of a normal rabbit. The problems mentioned in the introduction can be solved in other, though more tedious ways, by applying isotopic indicators, but a determination of the iron turnover cannot be considerate without the N E E Normal-Koninchen -pT-7 Introcelluldres Fe 1-r 1". 20 40 60 80 100 120 140 160 180 Fig. 9. Distribution of non-physiologicaly bound iron(lnigni) added to the plasma among the plasma, the intracellular space and the cellular space of a normal rabbit. Normal-Kaninchen = normal rabbit. Intracellulares Fe = intracellular iron. Lymphe Fe = lymph iron. Plasma Fe = plasmairon. 1 mgm citrate ^^Fe added as citrate. use of radioactive tracers. Use of these indicators provides a possibility of splitting up into components the dynamic equilibrium whose resultant is the plasma iron level. The result of splitting up this equilibrium directs our attention, with particular emphasis, to the importance of the de- ficient flow of iron from the storage organs into the plasma in infectious diseases and to some other pathological cases. In order to attain a per- manent increase in the plasma iron level in such diseases it would be necessary to increase the deficient flow into the plasma. That the lymph flow' plays a part in maintaining a normal plasma iron level is shown by the observation of Ehrenstein, viz. that the plasma iron level in a rabbit falls on the average from 191 to 146//gm % 4 hr after removal of the ductus thoracicus and the truncus jugularis sinister, whereas the level remains consta
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