. The American journal of roentgenology, radium therapy and nuclear medicine . hteen or twenty,from which the writer draws the conclusionthat acne may be produced by almost any- of The American Roentgen Ray Society, St. Louis, Mo.,I, 1921. Roentgen Ray Treatment of Acne Vulgaris 469 thing from indigestion to a state of exaltedself-consciousness. Recent authors haveadded little. Acne is characterized by several stages ofdevelopment rather than by distinct papules may remain as such for a con-siderable time and then undergo resolution,or they may increase in size until they be-come tub
. The American journal of roentgenology, radium therapy and nuclear medicine . hteen or twenty,from which the writer draws the conclusionthat acne may be produced by almost any- of The American Roentgen Ray Society, St. Louis, Mo.,I, 1921. Roentgen Ray Treatment of Acne Vulgaris 469 thing from indigestion to a state of exaltedself-consciousness. Recent authors haveadded little. Acne is characterized by several stages ofdevelopment rather than by distinct papules may remain as such for a con-siderable time and then undergo resolution,or they may increase in size until they be-come tubercles, or suppuration may takeplace within the sebaceous glands and the dermic abscesses may be formed. Semon,^in a recent article, mentions the fact thatperiglandular fibrosis occurs which is oftenexceedingly dense. He feels that this fibrosisprotects bacteria lying within the glandsfrom the action of vaccines. The diagnosis of acne should not be dif-ficult. The affection most likely to simulateacne is acnitis which has been called Dis-seminated Follicular Lupus, Acne Ro-. FiG. I. A portion of normal skin from the abdomenof a guinea pig showing a hair follicle to which isattached a sebaceous gland high up on the rightside as indicated by the arrow. The sebaceousglands in this region are all small. hair follicles, thereby producing of the pustules produces atrophicscars, pitting, and cicatricial tissue in theskin. Most investigators believe that the earlierlesions, that is, the small papules, resultfrom the infiltration of plasma cells, giantcells, mast cells and fusiform cells aboutthe outlets of the sebaceous glands. As theinfiltration continues and the entire glandand later the hair follicle are surrounded bythe infiltrating cells a large papule and final-ly a tubercle is formed. At times severalglands and follicles may be involved in onelesion. When suppuration sets in leukocytesappear and the glandular structure is des-troyed. In some cases the destructiv
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