. Ciba Foundation colloquia on ageing. Old age; Aging; Animals -- growth & development. Rapid Maturation and Ageing 199 subject for research, but it is possible that there was deficiency of riboflavin in some of his diets. Jolhffe and colleagues (JoUiffe, Funaro, Frontali, Maggioni, Corbo and Lanciano, 1953) have been studying the effect of vitamin Bjg (20 fig. daily) on the growth of Italian children, and in the initial seven months found a significant increase in weight. In the second year of study (Jolliffe, 1954, personal communication) significant increases in weight have again been f
. Ciba Foundation colloquia on ageing. Old age; Aging; Animals -- growth & development. Rapid Maturation and Ageing 199 subject for research, but it is possible that there was deficiency of riboflavin in some of his diets. Jolhffe and colleagues (JoUiffe, Funaro, Frontali, Maggioni, Corbo and Lanciano, 1953) have been studying the effect of vitamin Bjg (20 fig. daily) on the growth of Italian children, and in the initial seven months found a significant increase in weight. In the second year of study (Jolliffe, 1954, personal communication) significant increases in weight have again been found, but no significant increase in height, which is surprising since the INCAP workers concluded (1953) that "Throughout these studies, rate of gain in height has proved the more convincing variable". In India, it has been found that vitamin B^g appears to have no effect upon growth in undernourished children whose diets are inadequate (Annual Report, Nutrition Research Laboratories, Coonoor, 1953). We do not know why overfeeding produces early matura- tion. Overweight mothers tend to have large babies; so do diabetic mothers, perhaps because they have a greater ratio of glucagon to insulin and the former stimulates growth (Elrick, 1953). But the longer life-span of animals that are underfed during the growing period appears to be a general event occurring in animals that have no pancreas. If length of life-span is taken as a criterion, such animals should not perhaps be regarded as "underfed": their diet should be regarded as the "normal" one. Whatever the mechanism, I wish to repeat w^hat I have been maintaining for the past few years, that until we know more about the biological effects of overnutrition during childhood we should be careful of concluding that maximum growth is the optimupi. REFERENCES Benjamin, B., and Pirre, G. D. (1952). Lancet, i, 264. BoYNE, A. W., and Leitch, I. (1954). Nutr. Abs. Rev., 24, 255. Brody, S. (1945). Bioenerg
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