. Endocrinology. inguinalis combined with contralateral castration) in 3cases in producing phenomena which can be interpreted as acompensatory hypertrophy which, judged from everything, isdue alone to the Leydig cells. All of the groups of experiments corroborate, to the greatestextent, the theory that the Leydig cells are substantially the mostimportant for production of the male sexual hormones. Theseolder experiments from 1914 to 1917 I have taken up later. Asingle preliminary result of the new experiments I shall merely SAND 287 mention on account of its interest for the question of an eve
. Endocrinology. inguinalis combined with contralateral castration) in 3cases in producing phenomena which can be interpreted as acompensatory hypertrophy which, judged from everything, isdue alone to the Leydig cells. All of the groups of experiments corroborate, to the greatestextent, the theory that the Leydig cells are substantially the mostimportant for production of the male sexual hormones. Theseolder experiments from 1914 to 1917 I have taken up later. Asingle preliminary result of the new experiments I shall merely SAND 287 mention on account of its interest for the question of an eventualtransformation of connective tissue cells to Leydig cells. In some of the experiments on rats, which were examinedas early as three months afterwards, the inclosed testes werefound reduced to one-third of the weight of a normal controlanimals testes. The microscope showed—besides an advancedatrophy of the canals and a very considerable hypertrophy ofthe Leydig cells—a new phenomenon which, most probably,. Micropliotofrraph of normal testis from a pubescent the canals quite small groups of Leydig cells can be seen. escaped attention in the older experiments on account of thetreatment being with osmium (in the experiments dealt with hereformalin fixation and coloring by hematoxyline-eosine w^reused). In the intertubular tissue there were found, scatteredamong the ordinary connective tissue cells and the large groupsof Leydig cells (most often in between these) typical eosinophilecells, so numerous and constant that the phenomenon could notbe caused by chance. Although at present I cannot explain thispeculiar phenomenon, I am inclined to think that these cellspossibly represent a passing (transient) stage during a trans- 28b ENDOCRINOLOGY OF SEXUAL GLANDS formation of connective tissue cells to Leydig cells, especially inthe case where these are greatly augmented. ///. Experiments throwing light upon female sexual Transplantations I pe
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