. The American journal of roentgenology, radium therapy and nuclear medicine . leu-kocytic infiltration, tending to localize the effectsof the radiation. A glass tube containing was placed between the calvarium andscalp, and left in place for 30 days. Magnifica-tion, (For further reference see text.) chromatic bodies and Purkinji cells did notstain well. Plate IV shows a high power viewof the periphery of the lesion, which extendsbeyond the mid-line of the brain. Series B. Buried Radium EmanationTubes in Flexner-Johling Rat of the rapidity with which the
. The American journal of roentgenology, radium therapy and nuclear medicine . leu-kocytic infiltration, tending to localize the effectsof the radiation. A glass tube containing was placed between the calvarium andscalp, and left in place for 30 days. Magnifica-tion, (For further reference see text.) chromatic bodies and Purkinji cells did notstain well. Plate IV shows a high power viewof the periphery of the lesion, which extendsbeyond the mid-line of the brain. Series B. Buried Radium EmanationTubes in Flexner-Johling Rat of the rapidity with which the tu-mor cells respond to treatment, it was foundmore difficult to determine the area of ra-diated tissue about the radium tube in agrowing tumor than in normal tissues. In some cases the tumor was promptly reducedin size, but again, attending inflammationand edema may be considerable, and al-though the actual amount of living tumorcells is reduced, the total bulk of tissue mayappear increased. To determine the radium changes thatoccur in the transplantable rat carcinoma, the. Plate VI. This is a lesion produced by a singleradium emanation tube, containing about 2 mil-licuries, inserted in a carcinoma of the prostate;showing a central area of complete necrosis,with much leukocytic exudate, beyond whichthere are definite radium changes. technique of Series A was followed; 30 ra-dium tubes were inserted in tumors of dif-ferent sizes, and the tests were divided intothree groups: (i) The tumors were treatedfour weeks after transplantation, and theanimals were killed at the end of one, two,four and seven days respectively. (2) Tu-mors were treated with small doses of ra-dium, evenly distributed throughout thegrowth, and placed as nearly as possibleI cm. distance apart. (3) Radium tubes ofthe same strength were placed in tumors, The Action of Buried Tubes of Radium Emanation 541 but unevenly distributed, some of the tubesbeing more than i cm. apart. Although these experiments are still
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