. Radium, X rays and the living cell. cells which are indistinguishablefrom normal connective tissue cells. In the case ofljymphadeno-mata and carcinoma this evolution is admittedly difticult toestablish ; with sarcomata, on the other hand, the changes areplain and capable of easy demonstration. A sarcoma described by Faure-Beaulieu and Dominici(illustrated in Figs. 48, 49, and 50) ll serve as an example ofthis process. The growth sprang from the gum of the upperjaw in the situation formerly occupied by the left canine tooth MALIGNANT CELLS 263 (which had been lost from dental caries some fift
. Radium, X rays and the living cell. cells which are indistinguishablefrom normal connective tissue cells. In the case ofljymphadeno-mata and carcinoma this evolution is admittedly difticult toestablish ; with sarcomata, on the other hand, the changes areplain and capable of easy demonstration. A sarcoma described by Faure-Beaulieu and Dominici(illustrated in Figs. 48, 49, and 50) ll serve as an example ofthis process. The growth sprang from the gum of the upperjaw in the situation formerly occupied by the left canine tooth MALIGNANT CELLS 263 (which had been lost from dental caries some fifteen years pre-viously) and made its appearance about three months prior tothe commencement of treatment. Histological examination,made before irradiation was undertaken, revealed a typicalmyeloid sarcoma of a very vascular character. The treatmentwas commenced on the 12th September, 1908, and by the 20thJanuary, 1909, the growth had entirely disappeared and wasrepresented solely by a small fibrous scar. The changes accom- i v^ -^^. Fig. 49.—II, Section of the same tumour ninety days after tlic commencement of radiumtreatment. The greater part of the field is occupied by fibrous tissue, while the sarcomatouselements are reduced to isolated islands of cells. 97 diameters. Dominici, Archives de Medecim Gtnerale. 1909. 1 panying this regression of the tumour may be summarised in thethree following groups : (i) The metamorphosis of a part of the protoplasm of thegiant and other cells of the sarcoma into connective tissue fibres. (2) The conversion of the rest of the cytoplasm and of thenuclei of the sarcomatous elements into connective tissue cells. (3) The obhteration of the large blood spaces of the nuclei of the sarcoma cells, originally oval or round in outline, undergo marked elongation, while at the same timeatrophic changes are also distinguishable. The protoplasm of 264 MALIGNANT CELLS the giant cells and of the other sarcoma cells is replaced by
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