. The elements of pathological histology with special reference to practical methods . stroyed ganglion-cells and nerve-fibres occupied either by condensed neuroglia or by agelatinous tissue composed of branched cells and vessels. Sometimesthe neuroglia also may disappear, and in this case there ensues, byaccumulation of fluid, a formation, of small cysts traversed by delicatevessels. The microscopic appearances in this atropliy have already 342 THE CENTRAL NERVOUS SYSTEM been sketched above (p. 332), under the head of Chronic Polio-myelitis. Amongst the chronic inflammations many authorities
. The elements of pathological histology with special reference to practical methods . stroyed ganglion-cells and nerve-fibres occupied either by condensed neuroglia or by agelatinous tissue composed of branched cells and vessels. Sometimesthe neuroglia also may disappear, and in this case there ensues, byaccumulation of fluid, a formation, of small cysts traversed by delicatevessels. The microscopic appearances in this atropliy have already 342 THE CENTRAL NERVOUS SYSTEM been sketched above (p. 332), under the head of Chronic Polio-myelitis. Amongst the chronic inflammations many authorities reckon theprocess underlying dementia paralytica [or general 2)aralysis of theiTisane] and multiple cerehro-spinal sclerosis. In dementia paralytica,however, the primary element seems to be, not inflammatory change,but atrophy of the medullated nerve-fibres and of the ganglioniccells, especially in the frontal lobes. In this disease the ganglioniccells are destroyed in the manner described in speaking of chronicpoliomyelitis, though irregularly, all disappearing in some places, but. Fig. 1G7.—Multiple Sclerosis of the Spinal Cord. Low power (xl6). (Weigertshaematoxylin.) a, Sclerotic focus involving almost the entire lateral column, togetherwith the anterior and posterior horns of the same side. few in others; whilst the nerve-fibres, not only in the cortex butin other parts of the brain also, undergo atrophy to a greater orless extent. The larger the amount of nervous elements destroyed,the more conspicuous becomes a growth of the neuroglia, the cellsof the latter increasing in number and partly also in size, and thefibres becoming not only more numerous but thicker. There nextappear further changes which are undoubtedly of an inflammatorynature, viz., aggregations of leucocytes and sometimes also of redcorpuscles and grains of pigment in the perivascular spaces of thevessels of the cortex, and in many cases in those of the medullary MULTIPLE SCLEROSIS 343 centre also, toget
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Keywords: ., bookcentury1800, bookdecade1890, booksubjectpatholo, bookyear1895
