. The clonal selection theory of acquired immunity. Immunity; Cells. CLONAL SELECTION THEORY If the potential antigen persists long enough in high enough concentration, all clones which can produce this natural antibody will be eliminated. This provides a simple explana- tion for the red cell woagglutinins and could obviously be extended to cover all examples of prenatal tolerance. Self- not-self recognition means simply that all those clones which would recognize (that is, produce antibody against) a self component have been eliminated in embryonic life. All the rest are retained. O0O0O0 W O0
. The clonal selection theory of acquired immunity. Immunity; Cells. CLONAL SELECTION THEORY If the potential antigen persists long enough in high enough concentration, all clones which can produce this natural antibody will be eliminated. This provides a simple explana- tion for the red cell woagglutinins and could obviously be extended to cover all examples of prenatal tolerance. Self- not-self recognition means simply that all those clones which would recognize (that is, produce antibody against) a self component have been eliminated in embryonic life. All the rest are retained. O0O0O0 W O0®O'^0O©. oo ^. w^'' Fig. 7. To illustrate the clonal selection theory of immunity. Contact of the corresponding antigenic determinant with cells of clone c stimulates proliferation to antibody-producing plasma cells cp and non- antibody producing types c. To obtain such a result a fairly complex developmental sequence must be postulated. The first point to be considered is how a complete sequence of globulin patterns capable of reacting with all possible determinants could be established. There is a possible clue to be found in the fact that all substances capable of acting as antigens are susceptible to enzymic breakdown. Enzymes are proteins and it is probably a reasonable deduction that proteins have the potentiality of carrying steric patterns complementary to every chemical 59. Please note that these images are extracted from scanned page images that may have been digitally enhanced for readability - coloration and appearance of these illustrations may not perfectly resemble the original Burnet, F. M. (Frank Macfarlane), Sir, 1899-1985. Nashville, Vanderbilt University Press
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