. University of Toronto studies. Physiological series. no. 1-98. 1900-28 . ection was signaled on the record below the time special precautions were taken as to absolute uniformity in the rateof injection, but it was kept fairly constant, and was in all cases slow,as shown by the records. In some experiments we left the vagi intact; in the majority they werecut. We were unable to observe, however, any specific effect of theseon the reaction of any organ to adrenalin except the familiar one ofcardiac inhibition caused by large doses, with the consequent greatrise in blood pressure. Th
. University of Toronto studies. Physiological series. no. 1-98. 1900-28 . ection was signaled on the record below the time special precautions were taken as to absolute uniformity in the rateof injection, but it was kept fairly constant, and was in all cases slow,as shown by the records. In some experiments we left the vagi intact; in the majority they werecut. We were unable to observe, however, any specific effect of theseon the reaction of any organ to adrenalin except the familiar one ofcardiac inhibition caused by large doses, with the consequent greatrise in blood pressure. The oncometers which we used for kidney and for intestine weregutta percha ones of the ordinary type, fitted with glass lids. Theearly experiments on the spleen were done with the same oncometers;later we had a series of special ones made. These were modelled afterthe shape of the spleen (see fig. 1) and were provided with two lips forstalks, separated by about cm. in the smaller and cm. in thelarger. As recorders in the first few experiments we used Mareys drums;. DIFFERENTIAL ACTION OF ADRENALIN 313 later we substituted for these bellows recorders, which have the advan-tage of recording volume changes without introducing alterations ofpressure within the system itself. In several experiments the recorderswere calibrated by injections of known volumes of air. The pressure inside the system differed little from atmospheric;in practice we raised the pressure until the bellows were about halffilled, and were thus adjusted to give maximum variations in eitherdirection. INTESTINE A loop of the small intestine,about one-third of its total length,was selected, generally that imme-diately above the caecum, sincethe blood vessels there are longand form a convenient stalk. Twopairs of double ligatures were tiedabout its lower end, about 2 inchesapart, the blood vessels supplyingthe piece between the ligaturestied off, and the piece of intestineremoved. A similar operation wasperfo
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