. The Biological bulletin. Biology; Zoology; Biology; Marine Biology. .01 10 [DPBA] (uM) Figure 4. Concentration-dependence of DPBA effects on transmis- sion at the squid giant synapse. Combined results of experiments exam- ining both PSPs and PSCs reveal that DPBA concentrations as low as 50 nAI increase transmission, with larger effects produced by higher concentrations of DPBA. Points are means of 4 to 12 replicates, com- bining measurements on both PSPs and PSCs. and error bars indicate ±, when this value is larger than the symbol. Other PKC activators enhance transmission If
. The Biological bulletin. Biology; Zoology; Biology; Marine Biology. .01 10 [DPBA] (uM) Figure 4. Concentration-dependence of DPBA effects on transmis- sion at the squid giant synapse. Combined results of experiments exam- ining both PSPs and PSCs reveal that DPBA concentrations as low as 50 nAI increase transmission, with larger effects produced by higher concentrations of DPBA. Points are means of 4 to 12 replicates, com- bining measurements on both PSPs and PSCs. and error bars indicate ±, when this value is larger than the symbol. Other PKC activators enhance transmission If kinase C is involved in transmission at the squid syn- apse, then other PKC activators should produce changes in transmission similar to those produced by DPBA. The phorbol ester, tetradecanoyl phorbol-acetate (TPA), a compound used to activate PKC in a variety of experi- mental systems (Castagna eta/., 1982; Publicover, 1985; 1986;Shapira*Yfl/., 1987), was also capa- ble of enhancing synaptic transmission (Fig. 5A). The effects of TPA upon transmission appeared similar in magnitude (Table I) and time course to those of DPBA. although the example shown in Figure 5A illustrates an A B I uU Phorbol . 2 uM OPBA Q_ 1/1 Q_ ct o. Q_ CO Q_ 2 4 a: O. Please note that these images are extracted from scanned page images that may have been digitally enhanced for readability - coloration and appearance of these illustrations may not perfectly resemble the original Marine Biological Laboratory (Woods Hole, Mass. ); Marine Biological Laboratory (Woods Hole, Mass. ). Annual report 1907/08-1952; Lillie, Frank Rattray, 1870-1947; Moore, Carl Richard, 1892-; Redfield, Alfred Clarence, 1890-1983. Woods Hole, Mass. : Marine Biological Laboratory
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