Annals of surgery . dis-appear entirely from the immediate localities in which they lie. Tubercles are also formed. Rarely definite ones with centralgiant-cells are seen. About an exceptional parasite (rosette) andjust beyond a thin collar of leucocytes, the tissue elements pro-liferate, giving rise to the production of epithelioid cells, whichsurround these elements. In size they correspond with ordinarymiliary tubercles. 630 W. H. HUDSON AND SIMON FLEXNER. Changes occur in the epithehal cells, such as proliferationand desquamation, which are common. A rarer and more in-teresting process is t
Annals of surgery . dis-appear entirely from the immediate localities in which they lie. Tubercles are also formed. Rarely definite ones with centralgiant-cells are seen. About an exceptional parasite (rosette) andjust beyond a thin collar of leucocytes, the tissue elements pro-liferate, giving rise to the production of epithelioid cells, whichsurround these elements. In size they correspond with ordinarymiliary tubercles. 630 W. H. HUDSON AND SIMON FLEXNER. Changes occur in the epithehal cells, such as proliferationand desquamation, which are common. A rarer and more in-teresting process is the formation of multinucleated and giant-cells, within the alveoli, some of which show the radial arrange-ment of nuclei, so common in tuberculosis. The bronchi show exquisite inflammation. The exudate is,for the most part, composed of polymorpho-nuclear leucocytes,and is acute. But an older process, comparable to the olderobliterative pneumonia, in which fibrin is undergoing transfer- .41 f/^^ f^^y-^^^^^^^f .^•(5. Fig. I.—Minute structure of actinomycotic neoplasm (one-sixth inch objective) ; a single cluster of the ray fungus with zone of granulation tissue. mation into connective tissue, exists. Actual polypoid and con-centric masses of connective tissue project into or surround thelumina of these tubes. Skin.—The tissue subjected to microscopic study extendsto the superficial muscle. The sinus exists in all the depths ofthe sections and appears in communication with the external sur-face. The epithelial layer generally is of normal appearance; atthe edges of the sinuses the interpapillary processes are in activeproliferation and have undergone lengthening and branching. A C TINOM \ -COSIS HO MINIS. 631 The result is the not unusual picture of a typical epithelial growthseen about chronic skin ulcers. The deepest layer, that contain-ing muscular fibres, shows a condition of chronic inflammationassociated with increase in the sarcolemma nuclei. A markedinterstitial myos
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Keywords: ., bookcentury1800, bookdecade1880, booksubjectsurgery, bookyear1885
