Archives of internal medicine . his deterioration he found to be an excessive moisture con- 4. Focke: Therap. d. Gegenw., 1904, xlv, 250. w. F. BOOS—L. H. -NEWBURGH—H. K. MARX 555 tent of the powdered leaves. As a result of his tests Focke concludes thatthe deterioration in strength which occurs in the course of one year isproportional to the amount of moisture above 3 per cent, which is con-tained in the leaf-powder. Some powders which contained as much as8 per cent, moisture showed a loss in strength of over 60 per cent. Fockeprepared permanent leaf-powders in the following manner: he dried
Archives of internal medicine . his deterioration he found to be an excessive moisture con- 4. Focke: Therap. d. Gegenw., 1904, xlv, 250. w. F. BOOS—L. H. -NEWBURGH—H. K. MARX 555 tent of the powdered leaves. As a result of his tests Focke concludes thatthe deterioration in strength which occurs in the course of one year isproportional to the amount of moisture above 3 per cent, which is con-tained in the leaf-powder. Some powders which contained as much as8 per cent, moisture showed a loss in strength of over 60 per cent. Fockeprepared permanent leaf-powders in the following manner: he dried theleaves quickly with artificial heat at a temperature just below 100 C. untilthe moisture content was below per cent.; he then removed the thickstems, coarsely powdered the leaves and preserved them in air-tight the samples of leaf-powder prepared and preserved in this mannershowed no diminution in strength after one year. .^ ASPIRATIONS | PULSE-BEATS PER f TEMPERATURE. (FAHRENHEfT-S SCAtX). Chart 4.—Case 4. (Hosp. No. 165,693). Man aged 47. Myocardial insufficiency,mitral regurgitation (relative), broken compensation, edema of lungs, enlargedliver, edema of legs, infarct of lung involving whole right lower lobe. Markedgeneral improvement and efficient diuresis with second digipuratum cure. Dis-charged with fair compensation. Standardized leaf-powders prepared according to Fockes methodmay therefore be used for accurate dosage. There is, however, anotherfactor which often renders digitalis medication difficult and at times evenimpossible, namely, the tendency of leaf preparations to produce in manypatients gastro-enteric disturbances. Such disturbances are due, no doubt. 550 THE ARCHIVES OE IXTEIxXAL MEDICIXE in part if not wliolly to the presence in the leaves of digitonin. a constitu-ent of the digitalis leaf which is pharmacologically a saponin, the sapo-nins and sapotoxins being characterized by their irritant action on thegastro-ente
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