. The chemistry and physiology of growth. Growth; Biochemistry. THE SYNTHESIS OF PROTEINS 31 autocatalytic equation dv/dt = KV{Ve — V) when Ve = total concen- tration at end of reaction and V = concentration® of virus at time t. The explanation of the next step depends on whether or not the varia- tion in the number of virus molecules formed varies with the number of molecules with which the bacteria is infected. The direct experimental results show that it does, but Delbriick and Luria suggest that this is due to secondary reactions. If it be assumed that the number of molecules produced does
. The chemistry and physiology of growth. Growth; Biochemistry. THE SYNTHESIS OF PROTEINS 31 autocatalytic equation dv/dt = KV{Ve — V) when Ve = total concen- tration at end of reaction and V = concentration® of virus at time t. The explanation of the next step depends on whether or not the varia- tion in the number of virus molecules formed varies with the number of molecules with which the bacteria is infected. The direct experimental results show that it does, but Delbriick and Luria suggest that this is due to secondary reactions. If it be assumed that the number of molecules produced does vary with the size of the infection, then it must be assumed that the time re- quired for liberation of the virus depends to some extent on the bacteria cell and not entirely on the number of virus molecules present. There is some indication of this, since changing the temperature changes this time interval in the same way as it does the growth rate of the bacteria. We may assume that virus is liberated after a definite time has elapsed and that this time is determined both by the state of the bacteria cell and by the nature of the virus, but not by the number of molecules of virus. The theory of autocatalytic reaction applied to these conditions predicts that the number of molecules produced in the interval will in- crease more slowly than does the original number. Fig. 2 shows a series. 0 .4 .8 44 T Figure 2. Effect of initial concentration of the end product on an autocatalytic reaction. ^ It may be recalled in this connection that most enzyme reactions deviate from simple theory in that the velocity does not change in the expected way with either the enzyme or substrate concentration. In the case of the autocatalytic formation of pepsin from pepsinogen, for instance, increasing the concentration has much less effect on the velocity than predicted by the equation given above (Herriott, 1938).. Please note that these images are extracte
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