A text-book of pharmacology and therapeutics; or, The action of drugs in health and disease, . to beat for some time afterward. In frogs, no convulsions occur, the symi)toms pointing to a paralysisof the central nervous system without i)rcliminary stinudation, exceptin that the res])iration is somewhat (juick and dysi)naMC. In niaminals the Central Nervous System is first stimulated and thenparal\zcd. but the action seems to be dcv(>lopcd more fidl\ in the PRUSSIC ACID 451 incdiilla oblongata and lower parts of the brain tlian in the cerebralcortex, for the convulsions resemble those produc
A text-book of pharmacology and therapeutics; or, The action of drugs in health and disease, . to beat for some time afterward. In frogs, no convulsions occur, the symi)toms pointing to a paralysisof the central nervous system without i)rcliminary stinudation, exceptin that the res])iration is somewhat (juick and dysi)naMC. In niaminals the Central Nervous System is first stimulated and thenparal\zcd. but the action seems to be dcv(>lopcd more fidl\ in the PRUSSIC ACID 451 incdiilla oblongata and lower parts of the brain tlian in the cerebralcortex, for the convulsions resemble those produced by stimulation ofthe hind-brain, although the subsequent paralysis seems to include allparts of the central axis. The peripheral Muscles and the Nerves are weakened and eventuallyparalyzed when suspended in an atmosphere of the gas, but they arenot affected in poisoning; the nerves are more readily poisoned thanthe muscles. When prussic acid in solution is applied locally to theSkin it produces numbness and partial loss of sensation, but this doesnot follow in general poisoning. Fig. 62. Tracing of the movements of the diaphragm (respiration) of the rabbit under a largebut not fatal dose of cyanide of potassium injected intravenously. A-B, normal B 1 mg. injected; the respiratory movements are much larger. At C recovery. Notethe short duration of the stimulation. The Respiration is rendered quicker and deeper by the injection orinhalation of small quantities of prussic acid. After larger quantities,the acceleration is often interrupted by a prolonged pause after whichthe breathing returns spontaneously. In fatal poisoning no such returnoccurs, and after very large doses the breathing may cease within afew seconds. These changes are produced by primary stimulation andsubsequent paralysis of the medullary centre. The Circulation is altered mainly through the action on the centralnervous system, although prussic acid also acts directly on the stimulatio
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Keywords: ., bookcentury1900, bookdecade1910, booksubjecttherapeutics, bookyea
