. Elements of histology. Histology. chap, xxxii.] Female Genital Organs. 259 stroma. These follicles are spherical or slightly oval, of about yoV 0 nich m diameter, and each of them is limi- ted by a delicate membrana propria. Inside of this is a layer of flattened, transparent, ej)ithelial cells, each with an oval, flattened nucleus; this is the mem- brana granulosa. The space within the follicle is occupied by, and filled up with, a spherical cell—the ovum cell, or ovum. This is composed of a granular- looking protoplasm, and in this is a big spherical, or slightly oval, nucleus—the germinal
. Elements of histology. Histology. chap, xxxii.] Female Genital Organs. 259 stroma. These follicles are spherical or slightly oval, of about yoV 0 nich m diameter, and each of them is limi- ted by a delicate membrana propria. Inside of this is a layer of flattened, transparent, ej)ithelial cells, each with an oval, flattened nucleus; this is the mem- brana granulosa. The space within the follicle is occupied by, and filled up with, a spherical cell—the ovum cell, or ovum. This is composed of a granular- looking protoplasm, and in this is a big spherical, or slightly oval, nucleus—the germinal vesicle. The substance of this is either a fine reticulum; limited by a delicate membrane, with one or more nucleoli or germinal spots, or it is in one of the phases of indirect division or karyokinesis, thus indicating division of the ovum. 346. (c) From this cortical layer to the zona vasculosa we find embedded in the stroma isolated Graafian follicles, of various sizes, increasing from the former to the latter. The biggest follicles measure in diameter about — inch. Those of the middle layers are of medium size (Fig. 142). In them we find inside the membrana propria the membrana granulosa, made up of a single layer of transparent, columnar, epithelial cells. The ovum, larger than in the small cortical follicles, fills out the cavity of the follicle, and is limited by a thin hyaline cuticle—the zona pellucida. This appears as an excretion of the cells of the membrana granulosa. The protoplasm of the ovum is fibrillated. The part sur- rounding the germinal vesicle is more transparent, and stains differently in osmic acid than the peripheral part. The big nucleus, or germinal vesicle, is limited by a distinct membrane, and inside. Fig. 142.— A Small Gi-aafiau follicle, from tlie Ovary of Cat. The follicle is lined wi tli a layer of colum- nar epithelial cells— the membrana granu- losa. The ovum fills out the cavity of the follicle; it is sur- rounded by a thin zona
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