. Gynecology : . •P 2« Fig. 12.—Graafian Follicle from the Ovary of a Newborn clear space around the layer of epithelium is the result of an artefact in preparing the section. (After von Winckel.) 36 GYNECOLOGY the follicle. The tunica interna is also composed of connective tissue, but ismuch more cellular than the externa. These cells are large and rich in proto-plasm and are epithelioid in character. Toward the end of the ripening stagethey are actually larger than the epithelial cells of the membrana granulosa. Meanwhile the egg also undergoes a change. It becomes surrounded by a
. Gynecology : . •P 2« Fig. 12.—Graafian Follicle from the Ovary of a Newborn clear space around the layer of epithelium is the result of an artefact in preparing the section. (After von Winckel.) 36 GYNECOLOGY the follicle. The tunica interna is also composed of connective tissue, but ismuch more cellular than the externa. These cells are large and rich in proto-plasm and are epithelioid in character. Toward the end of the ripening stagethey are actually larger than the epithelial cells of the membrana granulosa. Meanwhile the egg also undergoes a change. It becomes surrounded by astrong homogeneous capsule, the zona pellucida. The protoplasm of the eggdoes not come in direct contact with the zona pellucida, there being betweenthe two the so-called perivitelline space, which contains fluid and in which the. Fig. 13.—Graafian power. In the center of the drawing is a follicle undergoing development. In the centerof the follicle is the ovum, which is surrounded by layers of cells constituting the membrana theca folliculi is not differentiated as yet. To the lower left side are two primordial follicles. egg enjoys a free movement. As the follicle develops the crescentic lake con-taining the liquor folliculi becomes more and more filled with fluid, which formsfrom a transudation of the vessels of the theca and from vacuolization of thegranulosa cells. It is a thin serous fluid containing albumin and is undoubt-edly a source of nourishment for the egg. The egg surrounded as it is by severalradiating layers of granulosa cells (the discus proligerus) does not come in directcontact with this fluid, but evidently receives nourishment from it through themedium of a fine intercellular network (paladinos), the fibrils of which reachthe zona pellucida. PHYSIOLOGY OF THE U
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