. Materia medica : pharmacology, therapeutics and prescription writing for students and practitioners. tion of phosphates is increased by water(Hawk), and possibly that of uric acid by atophan and piperazine. 3. Substances which are ordinarily reabsorbed are passed outin greater proportion to the other substances than normally, theirproportional reabsorption being prevented either by the morerapid flow which takes place through the tubules, or by impair-ment of the reabsorbing power of the cells. 4. Frequently, for the first day or two of diuresis there is agreat increase in the amount of some
. Materia medica : pharmacology, therapeutics and prescription writing for students and practitioners. tion of phosphates is increased by water(Hawk), and possibly that of uric acid by atophan and piperazine. 3. Substances which are ordinarily reabsorbed are passed outin greater proportion to the other substances than normally, theirproportional reabsorption being prevented either by the morerapid flow which takes place through the tubules, or by impair-ment of the reabsorbing power of the cells. 4. Frequently, for the first day or two of diuresis there is agreat increase in the amount of some of the solids excreted, as ifthere had been accumulation of these in the body and they werebeing washed out. Magnus says that for each salt (substance)there is a secretion threshold, a certain degree of concen-tration in the blood, above which an increase leads to the elimina-tion of the excess with an increased secretion of water. It may bethat in diuresis the level of this secretion threshold is lowered. 5. Without abundant supply of water there is no diuresis. 432 PHARMACOLOGY AND THERAPEUTICS. Fig. 52.—Drawing made to scale from tracings taken from a dog by C. C. line of figures, time in minutes. Black line, arterial pressure; dottedline, urine flow. The close relation between general blood-pressure and urine flowis striking. The drugs, in the order used, with dose per kilo, are: Cajjeine, 2 mg.,urine little affected. Theophylline acct-sodium, 3 mg., urine much of nitroglycerin, , urine decreased. Theobromine sodium salicylate,3 mg., urine increased. Caffeine and sodium benzoate, 4 mg., continues theo-bromine effect. Animal bled, 20 per kilo, great fall in urine. Saline infusion,25 per kilo, great increase. Camphor in oil, 20 mg., decided fall. Pituitaryextract, , fall followed by rise. Adrenaline solution, , fall followed byrise. Tincture of cantharides was then given in amounts large enough to produceinfla
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