Studies from the laboratories of the Deptof Surgery . Fig. 10.—Circulation of infants tibia and fibula (after Lexer.) : A, nutrientartery; B, metaphyseal capsular artery; C, relative avascular zone, where seques-trum separation usually occurs. that occurs in so many places in the body. Extraskeletal bone forma-tion occurs in one or more tissues in all of us if we live long enough,and it may be produced experimentally in animals without bone occurs frequently in man in the arterial wall and 12 in the muscles. It lias been described as ha\ iti<^ been lounJ in nearlyal
Studies from the laboratories of the Deptof Surgery . Fig. 10.—Circulation of infants tibia and fibula (after Lexer.) : A, nutrientartery; B, metaphyseal capsular artery; C, relative avascular zone, where seques-trum separation usually occurs. that occurs in so many places in the body. Extraskeletal bone forma-tion occurs in one or more tissues in all of us if we live long enough,and it may be produced experimentally in animals without bone occurs frequently in man in the arterial wall and 12 in the muscles. It lias been described as ha\ iti<^ been lounJ in nearlyall of the tissues of the body, such as the lymph nodes, ovaries, kidneys,fascial planes and wall of the orbii. Experimentally, bone has been produced in animals by ligating thevessels of the kidney and wrapping the omentum about it. Microscopicsections of this kidney from one to two months later show areas oftrue bone and calcification occurring in the parenchyma. NeuholT,. Fig. 11.—Roentgenogram of humerus, Nov. 3, 1919. Croton oil was insertedinto the medullary canal in capillary tube containers, Oct. 10, 1919: SQ,sequestrum; In, involucrum; S, separation zone. working in the labfjratory of surgical research at Columbia University,found bone almost universally in fascia lata transplants tliat he hadmade to fill a defect in the bladder. yy theory, therefore, tliat wemay accept should \>c broad enough to explain these irregular types ofbone formation as well as the repair of bone following fractures andinfection. We may. for the sake of discussion, classify the theorie.;of bone repair roughly into three groups: (\) periosteal; (2) osteo-blastic, and (3) extracellular deposition of calcium salts. 13 1. The periosteal theory presupposes that the periosteum andendosteum are definite organs for bone formation and repair, and thatthe bone cells arise from them and from no other source. 2. The osteoblastic theory may be divided into two subtitles. Type
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