. The Biological bulletin. Biology; Zoology; Biology; Marine Biology. CHEMORECEPTORS CONTROL CNIDA DISCHARGE Table V Dose-response parameters ofchemoreceptor-mediatedcnida discharge in Aiptasia pallida tentacles 169 .(mgf) IWmA/) K,(mA/) Glycine Alanine Proline Glutamine Histamine N-Acetylglucosamine N-Acetylneuraminic acid Submaxillary mucin ± ± ± ± ± ± ± ± X 10"2± X 10_2± X 10~2± X 10"2± X 10"2± ± ± ± ± ± 3.
. The Biological bulletin. Biology; Zoology; Biology; Marine Biology. CHEMORECEPTORS CONTROL CNIDA DISCHARGE Table V Dose-response parameters ofchemoreceptor-mediatedcnida discharge in Aiptasia pallida tentacles 169 .(mgf) IWmA/) K,(mA/) Glycine Alanine Proline Glutamine Histamine N-Acetylglucosamine N-Acetylneuraminic acid Submaxillary mucin ± ± ± ± ± ± ± ± X 10"2± X 10_2± X 10~2± X 10"2± X 10"2± ± ± ± ± ± ± ± ± no effect no effect no effect Em„ is the adhesive force (mgf) required to separate an adhering tentacle from the probe tip at maximum sensitization. The Ko5 represents the molar concentration of substance that half-maximally sensitizes the tentacle cnidocytes. Values of Emax and Ko 5 are determined from least-square double-reciprocal plots of the sensitization region of individual dose-response curves. K, represents the molar dissociation constant of the receptor- inhibitor complex for a competitive inhibitor (, diphenhydramine) and is obtained as the x-intercept from linear plots of the apparent Ko5 as a function of inhibitor concentration (Segal, 1976). The values of all parameters are expressed as means ± standard deviations. likely that these amino agonists occupy the same or sim- ilar chemoreceptors, whereas the K, value for glycine is significantly different. The antihistamines, PROLINE, M 1x 10 7 Figure 2. Double-reciprocal plots of proline-mediated sensitization in the presence of four different concentrations of diphenhydramine. The double-reciprocal plot of the sensitizing half of the biphasic dose- response curve is linear and yields Ko s and Ema, values from x- and y- intercepts, respectively. Increasing concentrations of diphenhydramine cause an increase in the apparent Ko5 value while not changin
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Keywords: ., bookauthorlilliefrankrat, booksubjectbiology, booksubjectzoology
