. Biology of the laboratory mouse. Mice as laboratory animals; Mice; Animals, Laboratory; Mice. SPONTANEOUS NEOPLASMS IN MICE 177 a connective tissue capsule which may be thick in some places and difficult to follow in others. The capsule is not invaded by the tumor cells. The epithelial cells are arranged as gland-Hke structures which are easily recog- nized as mammary gland in origin. These structures may vary considerably in size and arrangement, but they are always lined by a single layer of fairly uniform, usually small, and relatively inactive epithelial cells. Under these Cystic space E
. Biology of the laboratory mouse. Mice as laboratory animals; Mice; Animals, Laboratory; Mice. SPONTANEOUS NEOPLASMS IN MICE 177 a connective tissue capsule which may be thick in some places and difficult to follow in others. The capsule is not invaded by the tumor cells. The epithelial cells are arranged as gland-Hke structures which are easily recog- nized as mammary gland in origin. These structures may vary considerably in size and arrangement, but they are always lined by a single layer of fairly uniform, usually small, and relatively inactive epithelial cells. Under these Cystic space Epithelium Stroma Blood vessel. Fig. 90.—Simple adenoma of the mammary gland (X200'). cells the basement membrane remains intact and around this there are seen a few small, thread-like, wavy, spindle-shaped connective tissue cells. Simple adenoma of the mammary gland.—This is not commonly seen as such, but it is not rare to observe the remains of this type in direct continuity with carcinoma of the mammary gland. These adenomas contain gland-like arrangements of the mammar\^ epithelial cells (Fig. 90). They range from small abortive structures which appear to be attempts at gland formation to large, round or oval, dilated cyst-like spaces containing more or less eosino- philic amorphous material. The lining cells are arranged in a single, smooth, orderly layer. Generally they are cuboidal and uniform in size, shape and. Please note that these images are extracted from scanned page images that may have been digitally enhanced for readability - coloration and appearance of these illustrations may not perfectly resemble the original Roscoe B. Jackson Memorial Laboratory; Little, Clarence C. (Clarence Cook), b. 1888; Snell, George D. (George Davis), 1903-; Dingle, John H. (John Holmes), 1908-. Philadelphia, The Blakiston company
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