. Contributions from the Department of Neurology and the Laboratory of Neuropathology (reprints). frecpiently showed the loss of sensation, implicat-ing even the ear. Bladder and rectal control was lost,and the tendon reflexes were either diminished or ab-sent. These .•^ymjitoms occurred iimnediately or severalminntes after the injecticm was given, ami pei-sistcdfrom one to several hours. •4. Ilelin : Mih. i. klin. ( lilMli. xc. ?.-Ji1. Tlie permanent symptoms (/onsisted of ataxia, de-creased sensation, and. in Dog E. loss of patellar symptoms heeanR permanent after the third


. Contributions from the Department of Neurology and the Laboratory of Neuropathology (reprints). frecpiently showed the loss of sensation, implicat-ing even the ear. Bladder and rectal control was lost,and the tendon reflexes were either diminished or ab-sent. These .•^ymjitoms occurred iimnediately or severalminntes after the injecticm was given, ami pei-sistcdfrom one to several hours. •4. Ilelin : Mih. i. klin. ( lilMli. xc. ?.-Ji1. Tlie permanent symptoms (/onsisted of ataxia, de-creased sensation, and. in Dog E. loss of patellar symptoms heeanR permanent after the third injec-tion, remaining until the end of the experiment. Theataxia was recognized liy the irregular gait, and thetendency to stand with the iiind legs well apart, andthe peripheral part of tlie liind limbs well on the disturbances were demonstrated by the clip A lived one hour after the injection. Dog B fourhours. Dog ( seventeen days. Dog D 2 months and DogE forty-two days. The investigations liave not beencom]>letod. but the results olitained are Fig. 7.—Ouo of of hiud lei<.s. le ( (Hug 111 inimtiMl nn. sbuwing The alteiations of the cells of the anterior horns werenot im])ortant in any of the five dogs; in some slightcentral chromatolysis, and displacement and swellingof the nucleus were found. Dog D showed degenerationin the columns of GoU, more marked on one side, butdog E gave the most important results, and the follow-ing descrijjtiou is from the sections obtained in this case. Axis cylinders in tlie periphery of the anterolateral and pos-terior columns were found here and there considerably swollen:some were of large size: swollen cylinders were seen in the 10 root entrance zones of the posterior columns, but otherwise notin the posterior columns except near the peripliery. A mod-erate degree of cellular reaction to the stovain was detected intlie pia and roots of the cord in the


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