Modern surgery, general and operative . e some of the cases there is a tendencyto tumor formation. In the 67 cases col-lected by Packard and Steele, 3 sufferedfrom cancer and 5 from sarcoma. Inthe 158 cases collected by Higbee andEllis (Jour. Med. Research, vol. xxiv, No. i) there were 14 instances oftumor growth. In a case reported by Gruner, Scrimger, and Foster (Archivesof Internal Medicine, June, 1912) sarcoma appeared in the radius, head ofthe humerus, and other places. Some cases are associated with goiter. Ithas been suggested that there is a bacterial cause for Pagets disea
Modern surgery, general and operative . e some of the cases there is a tendencyto tumor formation. In the 67 cases col-lected by Packard and Steele, 3 sufferedfrom cancer and 5 from sarcoma. Inthe 158 cases collected by Higbee andEllis (Jour. Med. Research, vol. xxiv, No. i) there were 14 instances oftumor growth. In a case reported by Gruner, Scrimger, and Foster (Archivesof Internal Medicine, June, 1912) sarcoma appeared in the radius, head ofthe humerus, and other places. Some cases are associated with goiter. Ithas been suggested that there is a bacterial cause for Pagets disease. AnItalian investigator claimed to have discovered a bacterium and made a serumfor use in treatment. In 2 cases I exposed areas of new bone, removed por-tions, and took cultures. One set of cultures remained sterile. A tube of theother was found contaminated by the skin staphylococcus. Treatment is practically useless. No known remedy diminishes the size ofthe bones, although iodid of potassium is said occasionally to mitigate Fig. 259.—Pagets disease. Varieties of Fractures 513 Osteo=arthropathie Hypertrophiante Pneumique (Maries Dis-ease).—(See page 644.) Multiple Myeloma.—By this term we mean a new growth in the bone-marrow which occurs particularly in the ribs, sternum, and vertebrae. Itmay occur also in the bones of the cranium and in other bones. The multi-plicity is not due to metastasis, but the growths start as separate foci. Thenature of the cells in the growths is uncertain. They almost certainly springfrom marrow cells. Some consider them myelocytes, some bone-marrowplasma cells. The effect of the growth is to thin the bones and make them verybrittle. This condition was first described by Rustitzky in 1873. Stumm, whoreports 2 cases, estimates that about 50 cases have been reported. The condition begins insidiously, in either sex, during middle age, sometimesin advanced life. It begins usually with attacks of aching in the limbs andweakness. Such att
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