. Ciba Foundation colloquia on ageing. Old age; Aging; Animals -- growth & development. Discussion 83 number of deaths due to lung disease in the male. Unexplained deaths were due to vertigo as signs of destruction of one labyrinth were found (9-5 per cent in females, 8-5 per cent in males). Other causes of death which were diagnosed account for about 16 per cent. We have no obvious cases of nephrosis leading to death, but all rats over the age of 10 months have proteinuria and this becomes very high in some very old animals. Very old animals, of about 36 months, generally show no patholog
. Ciba Foundation colloquia on ageing. Old age; Aging; Animals -- growth & development. Discussion 83 number of deaths due to lung disease in the male. Unexplained deaths were due to vertigo as signs of destruction of one labyrinth were found (9-5 per cent in females, 8-5 per cent in males). Other causes of death which were diagnosed account for about 16 per cent. We have no obvious cases of nephrosis leading to death, but all rats over the age of 10 months have proteinuria and this becomes very high in some very old animals. Very old animals, of about 36 months, generally show no pathological findings which could explain their death. The possibility exists, therefore, that natural death may 20 n. 0 2 4 6 8 10 12 14 16 18 20 22 24 26 28 30 32 34 36 Age in months (7269) Fig. 2 (Verzar). occur without obvious illness being suffered. (About 15 per cent of our rats were not autopsied.) The survival curves show that after the 10th month "ageing" occurs at the same rate as resistance to external damage (infections) diminishes. This leads to maximal mortality at about 23-5 months, which is also the time of survival of 50 per cent of all individuals. Another point is that creatinuria in our rats begins at 500 days, at exactly the same time as the muscular dystrophy in Dr. Berg's rats. Creatinuria is also present with old age in man. Rockstein: How much, if at all, did you extend the life of those rats by restricted diets. Dr. Berg ? Berg: Lifespan studies have not been completed. At 800 days the survival rate of ad libitum-ied males was 48 per cent as compared. Please note that these images are extracted from scanned page images that may have been digitally enhanced for readability - coloration and appearance of these illustrations may not perfectly resemble the original Ciba Foundation; Wolstenholme, G. E. W. (Gordon Ethelbert Ward). Boston, Little, Brown
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