Collected papers . -^rt.^l^ai*-. J. S. D. del. \erlag von Giistav Fischer uiJciia --^ ?/eis e, L Uh., Journal Physiology, Vol. XLIII. I \Froiii the Proceedings of the Physiological Society, July 22, Note on the probable formation of adrenaline in the animalbody. By Casimir Funk. Some months ago theauthor prepared the 3-4 dihydroxyphenylalanineOH OH,- .CH.,—CH—COOH NH^ (which is probably present in small quantities in proteins) with the intention of ascertaining whether it might possibly be the precursor of adrenaline OH ohX\| n^CH—CHo—NH—CH3 OH Experiments showed that the compoun
Collected papers . -^rt.^l^ai*-. J. S. D. del. \erlag von Giistav Fischer uiJciia --^ ?/eis e, L Uh., Journal Physiology, Vol. XLIII. I \Froiii the Proceedings of the Physiological Society, July 22, Note on the probable formation of adrenaline in the animalbody. By Casimir Funk. Some months ago theauthor prepared the 3-4 dihydroxyphenylalanineOH OH,- .CH.,—CH—COOH NH^ (which is probably present in small quantities in proteins) with the intention of ascertaining whether it might possibly be the precursor of adrenaline OH ohX\| n^CH—CHo—NH—CH3 OH Experiments showed that the compound had practically no actionon the blood-pressure and was without any marked toxic power wheninjected. As many other catechol derivatives show very marked toxicand vaso-constricting actions, it appears probable that the presence ofthe side chain causes this difference in action. Experiments were carried out to ascertain if adrenaline could beobtained from the 3-4. dihydroxyphenylalanine by incubating withsuprarenal glan
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