. Calcified tissues; proceedings. Bone; Collagen; Calcification. Therapeutic Response and Effect on the Kidney of 100 Units Vitamin D 181 responded to 50 units of vitamin D. Fig. 3 shows the relation between the changes in the —- and the changes in the serum calcium and serum phosphorus in one patient Ccr p with severe osteomalacia. When the '' fell the serum calcium fell; the serum phos- Pgtienfs offerporfial gosfrectomy Vit D2 /0(>'M\ I I I wUh without osteomo/ocia <; ,____ _r^^ ^^^^ ~~~-^ --___ \ 1 1 ° mean value \ 1 1 ^/'^days 1 1 1 Fig. 2. Effect of daily Cp/Cer in 3 patients 6
. Calcified tissues; proceedings. Bone; Collagen; Calcification. Therapeutic Response and Effect on the Kidney of 100 Units Vitamin D 181 responded to 50 units of vitamin D. Fig. 3 shows the relation between the changes in the —- and the changes in the serum calcium and serum phosphorus in one patient Ccr p with severe osteomalacia. When the '' fell the serum calcium fell; the serum phos- Pgtienfs offerporfial gosfrectomy Vit D2 /0(>'M\ I I I wUh without osteomo/ocia <; ,____ _r^^ ^^^^ ~~~-^ --___ \ 1 1 ° mean value \ 1 1 ^/'^days 1 1 1 Fig. 2. Effect of daily Cp/Cer in 3 patients 6 8 Days jections 100 units ith osteomalacia itamin D 2 on nd 2 patients. Fig. 3. The serum a patient with injections of 100 units ate and Cp/Qr in d with four daily tamin D 2 phorus hardly changed. We draw 3 conclusions from these and other studies we have made: 1. The " may not be raised in osteomalacia. Ccr 2. When it is raised it may fall with the administration of 100 units of vitamin Do daily for 4 days. 3. In the patient whose serum calcium fell, the fall to a suppression of the parathyroid activity. The data suggest that a small dose of vitamin D may directly influence the tubular reabsorption of phosphorus in patients with osteomalacia. C,, ild ibuted Conclusion Patients with osteomalacia after gastrectomy get better with a dose of vitamin D^ equivalent to 130 units daily. While we do not suggest that this dose produces an optimal rate of healing, the clinical and biochemical response to this minute dose shows that these patients have a simple deficiency of vitamin D. The factors con- tributing to this deficiency have not been discussed. They involve both the patients' dietary intake which can be very small, and the patients' ability to absorb vitamin D, which may be Please note that these images are extracted from scanned page images that may have been digitally enhanced for readability - coloration and appearance of these illustrations may not perfec
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