Diffuse large B-cell lymphoma, light micrograph. Diffuse large B-cell lymphoma is the most common type of lymphoma and accounts for about 35% of all c

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Diffuse large B-cell lymphoma, light micrograph. Diffuse large B-cell lymphoma is the most common type of lymphoma and accounts for about 35% of all cases of non-Hodgkin lymphoma. It is an aggressive malignancy and presents with rapidly enlarging lymph nodes or tumor masses at extranodal sites. There is diffuse proliferation of large to medium-sized lymphoid cells which can be classified into centroblasts and immunoblasts. Some cases have markedly pleomorphic anaplastic cells. Primary testicular lymphomas are usually diffuse large B-cell type. The native seminiferous tubular architecture is completely destroyed and replaced by diffuse sheets of centroblasts, immunoblasts, or multilobated lymphoid cells. The periphery of the tumor shows interstitial growth with entrapment of tubules as shown in this low-power image.

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